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Skin Expression of Mammalian Target of Rapamycin and Forkhead Box Transcription Factor O1, and Serum Insulin-Like Growth Factor-1 in Patients with Acne Vulgaris and Their Relationship with Diet

research Skin expression of mammalian target of rapamycin and forkhead box transcription factor O1, and serum insulin‐like growth factor‐1 in patients with acne vulgaris and their relationship with diet

93 citations , January 2016 in “British Journal of Dermatology”

This study found that patients with acne vulgaris had higher serum IGF-1 levels and more intense FoxO1 and mTOR expression than controls, suggesting their role in acne pathogenesis.

research Mammalian target of rapamycin complex 1 (mTORC1) may modulate the timing of anagen entry in mouse hair follicles

28 citations , November 2012 in “Experimental dermatology”

This study suggests that mTORC1 may play a role in regulating the timing of hair growth cycle phases, particularly the initiation of the anagen phase.

research Molecular pathways involved in hair follicle tumor formation: all about mammalian target of rapamycin?

18 citations , January 2009 in “Experimental Dermatology”

This study proposes that mammalian target of rapamycin (mTOR) may connect various signaling pathways in hair follicle tumor formation, offering a potential unified model for understanding these tumors.

Fibrous Papule of the Face, Similar to Tuberous Sclerosis Complex-Associated Angiofibroma, Shows Activation of the Mammalian Target of Rapamycin Pathway: Evidence for a Novel Therapeutic Strategy?

research Fibrous Papule of the Face, Similar to Tuberous Sclerosis Complex-Associated Angiofibroma, Shows Activation of the Mammalian Target of Rapamycin Pathway: Evidence for a Novel Therapeutic Strategy?

12 citations , February 2014 in “PLoS ONE”

This study observed high expression of mTOR pathway effectors in fibrous papules and TSC-associated angiofibromas, suggesting that topical rapamycin might be an effective treatment for fibrous papules.

research Differential expression of phospho‐S6 in hair follicle tumors: Evidence of mammalian target of rapamycin pathway activation

4 citations , January 2019 in “Journal of cutaneous pathology”

This study found that phospho-S6 is strongly expressed in malignant hair follicle tumors but only patchily in a minority of benign tumors, indicating a potential marker for distinguishing between the two.

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community Everything you ever wanted to know about Pelage Pharma's PP405: how it works and what to expect

126 upvotes 3 months ago

PP405 may encourage earlier hair growth and slightly increase visible hair count but does not reverse hair follicle miniaturization in male pattern baldness. It does not address damage to the dermal papilla or broken Wnt signaling.

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learn Rapamycin

mTOR regulator and immunosuppressant used more recently for anti-aging and hair regrowth

What is rapamycin, and how is it being studied as a potential treatment for hair loss? Rapamycin is being studied for hair loss due to its effects on the mTOR pathway.
Can rapamycin be combined with other treatments like minoxidil or finasteride for better results? There are no published human trials of rapamycin combined with minoxidil or finasteride; the case for combining them is mechanistic theory only, and rapamycin for hair loss remains an off-label use of an immunosuppressant, so any combination is a decision for a prescriber.
Is rapamycin safe for long-term use on the scalp, or should it be used in cycles? There is no published human trial of topical rapamycin on the scalp, so nobody knows whether long-term use is safe; the idea of cycling it comes from community practice and theory, not from any study or guideline, and rapamycin for hair loss is an off-label use of a prescription immunosuppressant.

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Hair Transplant Surgeon
Dr. Rahma Targett, MD, FRACGP
Adelaide, SA, Australia

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Dr. Rahma Targett, MD, FRACGP