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GlossarymTOR (mammalian target of rapamycin)

regulates cell growth and metabolism in response to nutrients

mTOR, or the mechanistic target of rapamycin, is a protein that acts as a central regulator of cell growth, proliferation, and survival. It integrates signals from nutrients, growth factors, and cellular energy status to control processes like protein synthesis and autophagy. This pathway is significant in various biological contexts, including hair growth and alopecia, as it influences the activity of hair follicle cells.

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Skin Expression of Mammalian Target of Rapamycin and Forkhead Box Transcription Factor O1, and Serum Insulin-Like Growth Factor-1 in Patients with Acne Vulgaris and Their Relationship with Diet

research Skin Expression of Mammalian Target of Rapamycin and Forkhead Box Transcription Factor O1, and Serum Insulin-Like Growth Factor-1 in Patients with Acne Vulgaris and Their Relationship with Diet

93 citations, January 2016 in “British Journal of Dermatology”

Eating a high-glycemic diet may worsen acne by increasing certain protein levels and expressions in the skin.

research Mammalian Target of Rapamycin Complex 1 (mTORC1) May Modulate the Timing of Anagen Entry in Mouse Hair Follicles

28 citations, November 2012 in “Experimental dermatology”

A protein complex called mTORC1 likely affects when hair growth starts in mice.

research Differential Expression of Phospho-S6 in Hair Follicle Tumors: Evidence of Mammalian Target of Rapamycin Pathway Activation

4 citations, January 2019 in “Journal of cutaneous pathology”

The mTOR pathway may be involved in the development of hair follicle tumors, with higher activity in malignant tumors.

research Elevated Mammalian Target of Rapamycin Gene Expression in Acne Vulgaris Patients

January 2023 in “Al-Azhar International Medical Journal /Al-Azhar International Medical Journal”

Acne patients have higher mTOR gene expression.

research Expression of Steroidogenic Enzymes in Human Sebaceous Glands

25 citations, June 2014 in “Journal of Endocrinology/Journal of endocrinology”

Human sebaceous glands contain enzymes that affect androgen production and may influence sebum production and acne.

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community Fin/dut increase in estrogen and autoimmune diseases

in Chat 6 upvotes 1 year ago

The conversation discusses the link between increased estrogen and autoimmune diseases, with a focus on avoiding soy and milk. It also mentions treatments like Minoxidil, finasteride, and RU58841 for hair loss.

community Why Is Only Tressless Talking About Verteporfin? Healing Wounds With Zero Scarring Has Gargantuan Implications For All of Medicine. So What Gives?

in Research/Science 19 upvotes 2 years ago

The potential of verteporfin to heal wounds without scarring; however, despite its promising preclinical trials and coverage from a major media outlet, there is still no official clinical trial result and the drug has only garnered attention from hair loss communities.

community Every research project and treatment hope is failing it‘s insane

in Treatment 16 upvotes 5 years ago

The conversation expresses frustration over the lack of progress in hair loss treatments, with specific mentions of Minoxidil, finasteride, and RU58841. Users discuss the slow development of new treatments and the potential of hair transplants.

community Ejaculation & balding: NoFap has helped me stop my hair loss [case study]

37 upvotes 7 years ago

The user claims NoFap (abstaining from pornography, masturbation, and orgasm) helped stop their hair loss. Others argue that hair loss is primarily due to genetics and DHT, which can be managed with finasteride.

community How is it that golden era bodybuilders kept their hair while blasting gear while in the modern era most are bald? I’m convinced there’s something in our food and water causing MPB to speed up

in Satire 729 upvotes 1 year ago

The conversation is about the difference in hair loss between bodybuilders in the "Golden Era" and modern bodybuilders. Some users speculate that factors such as the types and doses of steroids used, genetics, diet, microplastics, and overall health may contribute to hair loss. Hair loss prevention medication and transplants are mentioned as potential treatments.

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