Selective Induction of Apoptosis in the Hamster Flank Sebaceous Gland Organ by a Topical Liposome 5-Alpha-Reductase Inhibitor: A Treatment Strategy for Acne

    February 2010 in “ Journal of Dermatology ”
    Lingna Li, Li Tang, Eugene Baranov, Meng Yang, Yasuyuki Amoh, Kensei Katsuoka, Robert M. Hoffman
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    TLDR A topical treatment safely and effectively reduced acne by causing targeted cell death in sebaceous glands without side effects.
    The study from 2010 investigated a topical liposome-encapsulated 5-α-reductase inhibitor, 4-MA, as a treatment for acne. It found that 4-MA effectively induced apoptosis in the sebaceous glands of hamster flank organs, reducing gland size and demonstrating selective efficacy without systemic side effects. The TUNEL method confirmed the selectivity of apoptosis, with many apoptotic cells in treated glands but few in surrounding tissues. The treatment did not affect hair follicles, melanin spots, internal organs, body weight, or testosterone/DHT ratios after 6 weeks. These results suggest that liposome 4-MA could be a safe and effective treatment for acne and potentially other androgen-dependent conditions.
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