Disturbed Epidermal Structure in Mice with Temporally Controlled Fatp4 Deficiency

The study examined the role of Fatp4 in the epidermis by creating mice with epidermal-specific Fatp4 deficiency, which led to hyperproliferative hyperkeratosis and a compromised epidermal barrier, similar to total Fatp4 deficiency. Despite these skin abnormalities, other organs remained normal. The findings underscored the importance of Fatp4 in maintaining skin integrity, particularly in keratinocytes, hair follicles, and sebaceous glands. Additionally, adult mice with inducible Fatp4 deficiency showed milder phenotypes than newborns, suggesting Fatp4's critical role in epidermal development. The study also noted significant changes in lipid composition, including an 80% increase in ceramide fraction and a decrease in very long chain fatty acids.