Disturbed Epidermal Structure in Mice with Temporally Controlled Fatp4 Deficiency

November 2005 in “ The journal of investigative dermatology/Journal of investigative dermatology ”

Thomas Herrmann, Hermann Josef Gröne, Lutz Langbein, Iris Kaiser, Isabella Gosch, Ute Bennemann, Daniel Metzger, Pierre Chambon, A. Francis Stewart, Wolfgang Stremmel

Fatp4 epidermal barrier hyperproliferative hyperkeratosis keratinocytes hair follicles sebaceous glands ceramide very long chain fatty acids skin barrier hair roots skin oil glands skin lipids

Studysummary The study concluded that fatty acid transport protein 4 in epidermal keratinocytes is crucial for maintaining normal skin structure, as its deficiency led to hyperkeratosis and epidermal barrier disruption in mice.

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The study investigated the role of Fatp4 in epidermal structure by creating mice with epidermis-specific Fatp4 deficiency using tamoxifen-induced Cre/lox conditional mutagenesis. The results showed that these mice developed hyperproliferative hyperkeratosis, disturbed epidermal barrier function, and significant abnormalities in skin structure, including increased cell layers and altered expression of differentiation markers. The compromised barrier was evidenced by the permeability to X-gal and Lucifer yellow dyes. The findings demonstrated that Fatp4 in epidermal keratinocytes was essential for maintaining normal epidermal structure and barrier function, potentially through its involvement in ceramide metabolism.

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