Transcriptome Profiling and Differential Gene Expression in Canine Microdissected Anagen and Telogen Hair Follicles and Interfollicular Epidermis

August 2020 in “ Genes ”

Dominique J Wiener, Kátia R. Groch, Magdalena A. T. Brunner, Tosso Leeb, Vidhya Jagannathan, Monika Welle

anagen telogen hair follicles interfollicular epidermis gene expression BMP2 BMP4 BMP7 KRT17 KRT25 differentially expressed genes molecular mechanisms hair growth hair loss growth phase resting phase skin

TLDR Different genes are active in dogs' hair growth and skin, similar to humans, which helps understand dog skin and hair diseases and can relate to human conditions.

The study "Transcriptome Profiling and Differential Gene Expression in Canine Microdissected Anagen and Telogen Hair Follicles and Interfollicular Epidermis" analyzed gene expression in different stages of hair follicle development and interfollicular epidermis (IFE) in dogs. Researchers identified distinct gene expression patterns associated with the anagen (growth) and telogen (resting) phases, highlighting genes like BMP2, BMP4, and BMP7 in anagen, and KRT17 and KRT25 in telogen. The study found 1,236 differentially expressed genes, with 858 upregulated in anagen and 378 in telogen. This research provided insights into the molecular mechanisms of hair growth and loss, suggesting dogs as a better model for human skin diseases compared to mice.

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