TLDR LGR5 and LGR6 are expressed differently in various skin tumors, which may offer clues about their origins.
The study analyzed the expression of stem cell markers LGR5 and LGR6 in 152 skin tumor samples, including 94 basal cell carcinomas (BCCs), 18 trichoepitheliomas (TEs), and other basaloid tumors. LGR5 was highly expressed in BCCs, TEs, and basaloid follicular hamartomas (BFHs), while LGR6 showed a similar but lower expression pattern, with unique expression in stromal cells around TEs and exclusively in basaloid cells of pilomatricomas (PMCs). The study concluded that LGR5 and LGR6 have distinct expression patterns in basaloid skin tumors, which could provide insights into their origin and development. The research was supported by the Korea Health Technology R&D Project and had no conflicts of interest.
326 citations,
February 2009 in “The American journal of pathology” Lgr5 is a marker for active, self-renewing stem cells in the intestine and skin, important for tissue maintenance.
835 citations,
October 2008 in “Nature Genetics” Lgr5 is a marker for active, long-lasting stem cells in mouse hair follicles.
9 citations,
January 2017 in “Virchows Archiv” LGR5 and LGR6 are expressed differently in various skin tumors, which may offer clues about their origins.
5 citations,
January 2016 in “Stem Cells International” Certain skin cells near the base of hair muscles may help renew and stabilize skin, possibly affecting skin disorder understanding.
326 citations,
February 2009 in “The American journal of pathology” Lgr5 is a marker for active, self-renewing stem cells in the intestine and skin, important for tissue maintenance.
835 citations,
October 2008 in “Nature Genetics” Lgr5 is a marker for active, long-lasting stem cells in mouse hair follicles.
34 citations,
June 2008 in “In vitro cellular & developmental biology. Animal” Scientists created a long-lasting stem cell line from human hair that can turn into different skin and hair cell types.
338 citations,
April 2001 in “Current Biology”
