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Glossary Stromal Cells

connective tissue cells supporting organ structure and function

Stromal cells are a type of connective tissue cell found in various organs, including the skin, bone marrow, and fat. They provide structural support and secrete factors that help regulate the function and growth of nearby cells, including those involved in hair growth and repair. For professionals, stromal cells are crucial in tissue engineering and regenerative medicine due to their role in creating a supportive microenvironment for tissue regeneration.

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Research

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research The Role of Stromal Stem Cells in Tissue Regeneration and Wound Repair

295 citations , June 2009 in “Science”

This article reviews the role of stromal stem cells in mammalian wound repair, suggesting they may perform functions similar to blastemal cells in simpler organisms, but reports no new experimental results.

research Conditioned Medium from Human Mesenchymal Stromal Cells: Towards the Clinical Translation

166 citations , April 2019 in “International Journal of Molecular Sciences”

The researchers reported that they predicted associations between certain components of MSC-conditioned medium and its ability to stimulate cell migration in vitro, identifying factors affecting its biological activity.

Activin Controls Skin Morphogenesis and Wound Repair Predominantly via Stromal Cells and in a Concentration-Dependent Manner via Keratinocytes

research Activin Controls Skin Morphogenesis and Wound Repair Predominantly via Stromal Cells and in a Concentration-Dependent Manner via Keratinocytes

81 citations , September 2005 in “The American journal of pathology”

This study found that activin affects both stromal cells and keratinocytes in skin morphogenesis and repair, with dose-dependent effects on keratinocytes demonstrated through transgenic mouse models.

research LL-37 stimulates the functions of adipose-derived stromal/stem cells via early growth response 1 and the MAPK pathway

53 citations , April 2016 in “Stem cell research & therapy”

This study reports that LL-37 treatment enhances cell proliferation, migration, and secretion of regenerative factors in adipose-derived stem cells, potentially promoting hair growth in vivo.

research Macrophage ferroportin is essential for stromal cell proliferation in wound healing

45 citations , August 2018 in “Haematologica”

This study found that iron retention in macrophages impairs hair follicle growth and delays wound healing in mice, highlighting the importance of macrophage iron release for skin health.

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community Conversation with 3-4 top dermatologists - no consensus

5 upvotes 4 months ago

Dermatologists have differing opinions on hair loss treatments, with some using topical dutasteride, oral minoxidil, exosome therapy, PRP, and various other therapies. The user plans to use a topical solution of dutasteride, minoxidil, tretinoin, PRP, and LLLT.

community Fresh off the press: Dutasteride may cause chronic infertility

in Research/Science 643 upvotes 1 year ago

Dutasteride may cause chronic infertility by reducing semen volume and motility, with concerns about irreversible prostate fibrosis. Users consider switching to finasteride or using treatments like minoxidil and microneedling, weighing hair preservation against fertility.

community How does dutasteride regrowth work?

in Finasteride/Dutasteride 7 upvotes 2 years ago

A 25-year-old man with hair loss from bleach damage is using oral minoxidil and considering adding Dutasteride for better regrowth and prevention. He seeks advice on Dutasteride's effectiveness and potential benefits over finasteride, and is also curious about RU58841.

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learn Grape stem cells

learn Apple stem cell

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