TLDR RANKL causes lymph nodes to grow by making certain cells multiply.
The study concluded that RANKL (Receptor Activator of Nuclear Factor Kappa-Β Ligand) was essential for the organized growth of lymph nodes by promoting the proliferation of stromal cells. This process was crucial for the development and maintenance of lymphoid tissue microarchitecture, which is vital for immune defense. The research, involving 11 Rank-Tg and 8 wild-type mice, demonstrated that RANKL from hair follicles induced lymph node hyperplasia, which could be normalized by blocking RANKL. The findings suggested potential therapeutic targets for diseases involving lymph node dysfunction and provided insights into immune system development and homeostasis.
60 citations,
March 2011 in “Proceedings of the National Academy of Sciences of the United States of America” RANK-RANKL signaling is essential for hair growth and skin health.
759 citations,
February 2009 in “Current Biology” Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.
60 citations,
March 2011 in “Proceedings of the National Academy of Sciences of the United States of America” RANK-RANKL signaling is essential for hair growth and skin health.
3 citations,
January 2024 in “Signal transduction and targeted therapy” Lymphatic vessels are essential for health and can be targeted to treat various diseases.
66 citations,
May 2021 in “Science Advances” Different scaffold patterns improve wound healing and immune response in mouse skin, with aligned patterns being particularly effective.
56 citations,
February 2010 in “PLOS ONE” Blocking Wnt signaling in young mice causes thymus shrinkage and cell loss, but recovery is possible when the block is removed.
46 citations,
August 2019 in “Journal of Ethnopharmacology” Eclipta prostrata has many traditional uses and health benefits, but more research is needed to understand how it works and ensure it's safe.
