RANKL Induces Organized Lymph Node Growth by Stromal Cell Proliferation

    December 2011 in “ ˜The œjournal of immunology/˜The œJournal of immunology ”
    Estelle Hess, Vincent Duhéron, Marion Décossas … Christopher G. Mueller
    Studysummary In this study, transgenic mice with Rank expression in hair follicles showed excessive lymph node growth, which could be normalized by neutralizing the overproduced RANKL, underscoring its role in immune system regulation.
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    Research cited in this study 3

    1. Receptor Activator of NF-κB Stimulates the Proliferation of Epithelial Cells of the Epidermo-Pilosebaceous Unit Proceedings of the National Academy of Sciences of the United States of America · 2011
    2. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    3. Cyclic Alopecia in Msx2 Mutants: Defects in Hair Cycling and Hair Shaft Differentiation Development · 2002