TLDR LL-37 helps stem cells grow and move, aiding tissue regeneration and hair growth.
The study demonstrated that the antimicrobial peptide LL-37 significantly enhanced the proliferation, migration, and regenerative functions of adipose-derived stromal/stem cells (ASCs) through the early growth response 1 (EGR1) and mitogen-activated protein kinase (MAPK) pathways. LL-37 treatment increased the expression of EGR1 and the secretion of growth factors such as VEGF, thymosin beta-4, MCP-1, and SDF-1. Conditioned medium from LL-37-preconditioned ASCs promoted hair growth in vivo in mice, achieving 95-100% hair regeneration compared to 30-35% in non-activated ASCs. These findings suggested that LL-37 could be used to enhance the therapeutic potential of ASCs for tissue regeneration and hair growth.
35 citations,
March 2015 in “Experimental Dermatology” Cells from the base of hair follicles help blood vessel cells survive and grow, which is important for healthy hair.
11 citations,
March 2015 in “Life sciences” Vitamin D3-activated cell byproduct promotes hair growth in mice by increasing blood vessel growth.
30 citations,
October 2013 in “BMC dermatology” VEGF gel increases hair growth but may have potential toxicity.
134 citations,
January 2010 in “Biomedical research” Low oxygen conditions increase the hair-growing effects of substances from fat-derived stem cells by boosting growth factor release.
40 citations,
October 2002 in “Endocrinology” Vitamin D3 analogs can promote hair growth in mice genetically prone to hair loss.
136 citations,
May 2019 in “Cells” Stem cell therapy, particularly using certain types of cells, shows promise for treating hair loss by stimulating hair growth and development, but more extensive trials are needed to confirm these findings.
76 citations,
January 2017 in “World Journal of Stem Cells” Fat tissue cells are a promising option for healing various diseases, but more research is needed to ensure they are safe and effective.
42 citations,
February 2018 in “International Journal of Molecular Sciences” Minoxidil boosts hair growth by triggering growth factor release from specific stem cells.
12 citations,
August 2018 in “Journal of Dermatological Science” Scientists made stem cells that can grow hair by adding three specific factors to them.
January 2022 in “Stem cell biology and regenerative medicine” Stem cell therapies show promise for hair regrowth but need more research to confirm effectiveness.
