LL-37 Stimulates the Functions of Adipose-Derived Stromal/Stem Cells via Early Growth Response 1 and the MAPK Pathway

April 2016 in “ Stem cell research & therapy ”

Yoolhee Yang, Hojong Choi, Mira Seon, Daeho Cho, Sa Ik Bang

LL-37 adipose-derived stromal/stem cells early growth response 1 mitogen-activated protein kinase VEGF thymosin beta-4 MCP-1 SDF-1 hair growth tissue regeneration ASCs EGR1 MAPK vascular endothelial growth factor monocyte chemoattractant protein-1 stromal cell-derived factor-1

Studysummary This study reports that LL-37 treatment enhances cell proliferation, migration, and secretion of regenerative factors in adipose-derived stem cells, potentially promoting hair growth in vivo.

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The study demonstrated that the antimicrobial peptide LL-37 significantly enhanced the proliferation, migration, and regenerative functions of adipose-derived stromal/stem cells (ASCs) through the early growth response 1 (EGR1) and mitogen-activated protein kinase (MAPK) pathways. LL-37 treatment increased the expression of EGR1 and the secretion of growth factors such as VEGF, thymosin beta-4, MCP-1, and SDF-1. Conditioned medium from LL-37-preconditioned ASCs promoted hair growth in vivo in mice, achieving 95-100% hair regeneration compared to 30-35% in non-activated ASCs. These findings suggested that LL-37 could be used to enhance the therapeutic potential of ASCs for tissue regeneration and hair growth.

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