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GlossaryMonocyte Chemoattractant Protein-1 (MCP-1)

signaling protein that attracts monocytes to inflammation sites

Monocyte Chemoattractant Protein-1 (MCP-1), also known as CCL2, is a signaling protein that plays a crucial role in the immune system by attracting monocytes, a type of white blood cell, to sites of inflammation or injury. This protein is important in the body's response to infection and tissue damage, but excessive MCP-1 activity can contribute to chronic inflammatory diseases.

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research Oral Contraceptive Pill Treatment Alters Gene Expression of Inflammatory Markers in Polycystic Ovary Syndrome Women

2 citations , February 2023 in “BMC women's health”

Birth control pills change the activity of certain inflammation and blood clotting genes in women with PCOS.

research Different Levels of EGF, VEGF, IL-6, MCP-1, MCP-3, IP-10, Eotaxin, and MIP-1α in the Adipose-Derived Stem Cell Secretome in Androgenetic Alopecia

1 citations , February 2022 in “Experimental Dermatology”

Certain proteins are found at higher levels in balding areas compared to non-balding areas, suggesting a link to hair loss. This could be useful for diagnosing and treating hair loss.

research Different Levels of EGF, VEGF, IL-6, MCP-1, MCP-3, IP-10, Eotaxin and MIP-1α in Adipose Derived Stem Cells Secretome in Androgenetic Alopecia

January 2021

Higher levels of certain proteins in hair loss areas may help understand and treat hair loss.

research Effects of Calcitriol Combined with Metformin in the Treatment of Polycystic Ovary Syndrome and Its Influence on Serum Monocyte Chemotactic Factor-1

March 2017

Calcitriol and metformin together are more effective for treating PCOS and lowering MCP-1 than metformin alone.

research LL-37 Stimulates the Functions of Adipose-Derived Stromal/Stem Cells via Early Growth Response 1 and the MAPK Pathway

53 citations , April 2016 in “Stem cell research & therapy”

LL-37 helps stem cells grow and move, aiding tissue regeneration and hair growth.

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community PP405 Identity Research

in Research 292 upvotes 1 month ago

PP405 is a potential hair loss treatment that inhibits mitochondrial pyruvate carriers, increasing lactate dehydrogenase activity and stimulating hair follicle stem cells. In a phase 1 trial, 31% of participants showed over 20% hair density increase with PP405 treatment.