TLDR Birth control pills change the activity of certain inflammation and blood clotting genes in women with PCOS.
The study examined the effects of oral contraceptive pills (OCPs) on gene expression in 50 women with polycystic ovary syndrome (PCOS), comparing 25 OCP-treated women to 25 drug-naive women. Results showed that OCP treatment significantly increased the mRNA expression of inflammatory markers ICAM-1 (2.54-fold), TNF-α (2.05-fold), and MCP-1 (1.74-fold), while PAI-1 expression remained unchanged. These changes correlated with higher BMI, triglycerides, blood glucose, and insulin levels, suggesting that OCPs may exacerbate inflammatory and metabolic disturbances in PCOS patients, despite their benefits in reducing hyperandrogenism and regularizing menstrual cycles.
28 citations,
November 2019 in “Frontiers in Endocrinology” Vegetarian Indian women with PCOS have higher inflammation levels than non-vegetarians.
17 citations,
May 2019 in “Diabetes and Metabolic Syndrome: Clinical Research and Reviews” High fasting insulin levels in women with PCOS are linked to a higher risk of heart and metabolic problems.
research Acne
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January 2004 in “Fertility and Sterility” The 2003 consensus updated PCOS diagnosis criteria and highlighted increased risks of diabetes and heart disease for those affected.
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December 2011 in “Fertility and sterility” Experts agree that PCOS affects women's health in complex ways, but more research is needed to understand and treat it effectively.
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200 citations,
October 2009 in “European journal of endocrinology” Metformin helps manage polycystic ovary syndrome by improving insulin resistance and ovulation, but more research is needed on its full effects.
317 citations,
April 2018 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology” PCOS is a complex condition in women that can lead to health issues, and lifestyle changes are the best management approach.
October 2023 in “Frontiers in endocrinology” Effective PCOS treatments require targeting specific signaling pathways.
