Acne

    April 2005 in “ The New England Journal of Medicine ”
    William D. James
    Image of study
    TLDR Acne affects most teenagers and can continue into adulthood, with various treatments available that show improvement but have concerns like antibiotic resistance and side effects.
    The 2005 article from the New England Journal of Medicine discussed acne as a prevalent condition affecting over 85% of teenagers and persisting into adulthood, with significant social and emotional impacts. It described acne as a follicular disease with contributions from androgens and Propionibacterium acnes. Various treatments were reviewed, including topical retinoids, antimicrobials like benzoyl peroxide, combination therapies, oral antibiotics for moderate-to-severe cases, hormonal agents for women, and isotretinoin for severe cases. The article noted a 50 to 60 percent improvement with oral antibiotics, but raised concerns about antibiotic resistance. Hormonal therapy showed a 30 to 60 percent reduction in lesions, while isotretinoin was highly effective but had serious side effects. The need for more randomized controlled trials was emphasized to guide therapy choices, and a combination of topical and oral therapy was recommended for moderately severe acne.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    6 / 773 results
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 1 year ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

      in Research/Science  64 upvotes 1 year ago
      Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

      community RU58841 has gotten rid of my acne

      in Product  1 upvotes 1 month ago
      RU58841, combined with 5% minoxidil, helped reduce acne and hair loss. Users discussed using RU58841 cream for acne and shared experiences with other treatments like finasteride and dutasteride.

      community Are any of you using topical spironolactone ?

      in Treatment  4 upvotes 1 month ago
      The user is using topical dutasteride, minoxidil, and spironolactone for hair loss, with positive results after adding spironolactone. Another user takes oral spironolactone, dutasteride, and finasteride, noting decreased libido but no major side effects.

    Related Research

    1 / 1 results