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GlossaryPlasminogen Activator Inhibitor-1

regulates blood clot breakdown by inhibiting plasminogen conversion enzymes

Plasminogen Activator Inhibitor-1 (PAI-1) is a protein that regulates the breakdown of blood clots by inhibiting enzymes that convert plasminogen to plasmin, which is responsible for clot degradation. Elevated levels of PAI-1 are associated with an increased risk of thrombosis and various cardiovascular diseases, as it can lead to excessive clot formation.

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research Role of plasminogen activator inhibitor type 1 (PAI-1) in PCOS patient

3 citations , August 2017 in “International journal of reproduction, contraception, obstetrics and gynecology”

People with PCOS have higher levels of PAI-1, which may increase their risk of heart disease and fertility issues.

Oral contraceptive pill (OCP) treatment alters the gene expression of intercellular adhesion molecule-1 (ICAM-1), tumor necrosis factor-α (TNF-α), monocyte chemoattractant protein-1 (MCP-1) and plasminogen activator inhibitor-1 (PAI-1) in polycystic ovary syndrome (PCOS) women compared to drug-naive PCOS women

research Oral contraceptive pill (OCP) treatment alters the gene expression of intercellular adhesion molecule-1 (ICAM-1), tumor necrosis factor-α (TNF-α), monocyte chemoattractant protein-1 (MCP-1) and plasminogen activator inhibitor-1 (PAI-1) in polycystic ovary syndrome (PCOS) women compared to drug-naive PCOS women

2 citations , February 2023 in “BMC women's health”

Birth control pills change the activity of certain inflammation and blood clotting genes in women with PCOS.

research Localization of Plasminogen Activator Inhibitor Type 2 (PAI-2) in Hair and Nail: Implications for Terminal Differentiation

42 citations , June 1998 in “The journal of investigative dermatology/Journal of investigative dermatology”

PAI-2 helps in the maturation and protection of hair and nail cells.

research Evaluation of cardiac risk marker levels in obese and non-obese patients with polycystic ovaries

21 citations , July 2016 in “Gynecological Endocrinology”

Obese and non-obese women with PCOS have higher heart risk markers, especially if they are obese.

research Wound healing in development

29 citations , September 2012 in “Birth Defects Research”

Wounds heal without scarring in early development but later result in scars, and studying Wnt signaling could help control scarring.

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