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GlossaryPlasminogen Activator Inhibitor-1

regulates blood clot breakdown by inhibiting plasminogen conversion enzymes

Plasminogen Activator Inhibitor-1 (PAI-1) is a protein that regulates the breakdown of blood clots by inhibiting enzymes that convert plasminogen to plasmin, which is responsible for clot degradation. Elevated levels of PAI-1 are associated with an increased risk of thrombosis and various cardiovascular diseases, as it can lead to excessive clot formation.

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research Role of Plasminogen Activator Inhibitor Type 1 (PAI-1) in PCOS Patients

3 citations, August 2017 in “International journal of reproduction, contraception, obstetrics and gynecology”

People with PCOS have higher levels of PAI-1, which may increase their risk of heart disease and fertility issues.

research Oral Contraceptive Pill Treatment Alters Gene Expression of Inflammatory Markers in Polycystic Ovary Syndrome Women

2 citations, February 2023 in “BMC women's health”

Birth control pills change the activity of certain inflammation and blood clotting genes in women with PCOS.

research Thrombin Activatable Fibrinolysis Inhibitor and Other Hemostatic Parameters in Patients with Polycystic Ovary Syndrome

29 citations, January 2009 in “Gynecological Endocrinology”

Women with PCOS have higher levels of certain blood clotting factors, suggesting a greater risk of cardiovascular issues.

research Localization of Plasminogen Activator Inhibitor Type 2 in Hair and Nail: Implications for Terminal Differentiation

42 citations, June 1998 in “The journal of investigative dermatology/Journal of investigative dermatology”

PAI-2 helps in the maturation and protection of hair and nail cells.

research Evaluation of Cardiac Risk Marker Levels in Obese and Non-Obese Patients with Polycystic Ovaries

21 citations, July 2016 in “Gynecological Endocrinology”

Obese and non-obese women with PCOS have higher heart risk markers, especially if they are obese.

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