Adipose-Derived Stromal Cells in Regenerative Medicine: A Review

January 2017 in “ World Journal of Stem Cells ”

Reza Tabatabaei Qomi, Mohsen Sheykhhasan

adipose-derived stromal cells ADSCs regenerative medicine hair loss immune modulation anti-inflammatory properties fat-derived stem cells

Studysummary This review discusses the potential applications of adipose-derived stromal cells for treating conditions like colitis, liver failure, and more, without presenting new clinical results.

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research Human Mesenchymal Stem Cell-Derived Conditioned Media for Hair Regeneration Applications

9 citations , June 2017 in “PubMed”

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research Mesenchymal Stem Cells from Adipose Tissue in Clinical Applications for Dermatological Indications and Skin Aging

132 citations , January 2017 in “International Journal of Molecular Sciences”

This review explores how adipose-derived stem cells contribute to skin homeostasis and highlights recent advances in their clinical applications in dermatology, but it reports no new clinical results.

research Assembling Composite Dermal Papilla Spheres with Adipose-Derived Stem Cells to Enhance Hair Follicle Induction

37 citations , May 2016 in “Scientific Reports”

In this study, the researchers found that using a core-shell assembly of adipose-derived stem cells and dermal papilla cells reconstructed hair follicle cellular arrangements more effectively than mixed assemblies, enhancing hair formation in vivo.

research LL-37 Stimulates the Functions of Adipose-Derived Stromal/Stem Cells via Early Growth Response 1 and the MAPK Pathway

53 citations , April 2016 in “Stem cell research & therapy”

This study reports that LL-37 treatment enhances cell proliferation, migration, and secretion of regenerative factors in adipose-derived stem cells, potentially promoting hair growth in vivo.

research Hair Regeneration Using Adipose-Derived Stem Cells

17 citations , March 2016 in “PubMed”

This review discusses the potential and limitations of adipose-derived stem cells and their conditioned medium for hair regeneration, highlighting novel preconditioning methods to enhance their effectiveness, without presenting new clinical results.

Hair Growth Promoting Effect of Dermal Papilla-Like Tissues from Canine Adipose-Derived Mesenchymal Stem Cells Through Vascular Endothelial Growth Factor

research Hair Growth Promoting Effect of Dermal Papilla-Like Tissues from Canine Adipose-Derived Mesenchymal Stem Cells Through Vascular Endothelial Growth Factor

8 citations , January 2016 in “Journal of Veterinary Medical Science”

This study found that canine adipose-derived mesenchymal stem cell-derived dermal papilla-like tissues promoted new hair follicle formation and increased vascularization in mice, suggesting potential for hair regeneration.

research Clinical Use of Conditioned Media of Adipose Tissue-Derived Stem Cells in Female Pattern Hair Loss: A Retrospective Case Series Study

83 citations , March 2015 in “International Journal of Dermatology”

This retrospective study found that adipose-derived stem cell-conditioned media increased hair density and thickness in women with female pattern hair loss over 12 weeks, with no severe adverse effects reported.

research Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling

499 citations , September 2011 in “Cell”

This study found that intradermal adipocyte lineage cells in mice are necessary and sufficient to activate follicular stem cells, highlighting their role in regulating skin stem cell activity.

Hair Growth Stimulated by Conditioned Medium of Adipose-Derived Stem Cells Is Enhanced by Hypoxia: Evidence of Increased Growth Factor Secretion

research Hair Growth Stimulated by Conditioned Medium of Adipose-Derived Stem Cells Is Enhanced by Hypoxia: Evidence of Increased Growth Factor Secretion

134 citations , January 2010 in “Biomedical research”

This study found that subcutaneous administration of conditioned medium from adipose-derived stem cells promoted hair growth in mice, and hypoxia enhanced this effect by altering growth factor secretion.