Hair Growth Promoting Effect of Dermal Papilla-Like Tissues from Canine Adipose-Derived Mesenchymal Stem Cells Through Vascular Endothelial Growth Factor

The study demonstrated that dermal papilla-like tissues (DPLTs) derived from canine adipose-derived mesenchymal stem cells (ASCs) could promote hair growth by forming structures similar to natural dermal papillae and secreting vascular endothelial growth factor (VEGF). The DPLTs were injected into skin wounds of thirty athymic nude mice, which were then observed for hair follicle formation, vascularization, and VEGF secretion at intervals of 10, 20, and 30 days. The results showed significant hair follicle regeneration and increased angiogenesis in the DPLTs group compared to the control group, particularly at days 10 and 20 post-injection. By day 30, the differences were not significant. The study concluded that DPLTs have the potential to serve as an alternative therapy for hair regeneration, particularly in alopecic animals, by enhancing hair follicle regeneration and neovascularization. However, the study acknowledged limitations and called for further research to explore additional paracrine and signaling pathways involved in hair regeneration.