Application of Mesenchymal Stem Cells Derived from Bone Marrow and Umbilical Cord in Human Hair Multiplication

September 2010 in “ Journal of dermatological science ”

Bo-Young Yoo, Youn-Ho Shin, Hee-Hoon Yoon, Young-Kwon Seo, Kye‐Yong Song, Jung-Keug Park

mesenchymal stem cells bone marrow umbilical cord alopecia hair multiplication dermal papilla-like tissues dermal papilla cells hair follicle formation hair cell therapy MSCs DPLTs

TLDR Bone marrow and umbilical cord stem cells can help grow new hair.

The study investigated the potential of mesenchymal stem cells (MSCs) derived from human bone marrow and umbilical cord for treating alopecia by inducing hair multiplication. Researchers isolated and cultivated these MSCs to form dermal papilla-like tissues (DPLTs), which were tested in vitro and in vivo using athymic mice. The DPLTs exhibited similar characteristics to natural dermal papilla cells and successfully induced new hair follicle formation. The findings suggested that MSCs from bone marrow or umbilical cord could be promising sources for human hair cell therapy.

View this study on jdsjournal.com →

Discuss this study in the Community →

Research cited in this study

6 / 6 results

research Hair Follicular Cell/Organ Culture in Tissue Engineering and Regenerative Medicine

21 citations, October 2009 in “Biochemical Engineering Journal”

Stem cell therapy is a promising approach for hair regrowth despite potential side effects.

research Hair Morphogenesis In Vitro: Formation of Hair Structures Suitable for Implantation

43 citations, August 2008 in “Regenerative Medicine”

Scientists created early-stage hairs from mouse cells that grew into normal, pigmented hair when implanted into other mice.

research Microencapsulated Human Hair Dermal Papilla Cells: A Substitute for Dermal Papilla?

25 citations, April 2008 in “Archives of Dermatological Research”

Encapsulated human hair cells can substitute for natural hair cells to grow hair.

research Biological Characterization of Cultured Dermal Papilla Cells and Hair Follicle Regeneration In Vitro and In Vivo

24 citations, February 2006 in “Chinese Medical Journal”

Cultured dermal papilla cells can regenerate hair follicles and sustain hair growth.

research Hair Matrix Germinative Epidermal Cells Confer Follicle-Inducing Capabilities on Dermal Sheath and High Passage Papilla Cells

61 citations, October 1996 in “Development”

Hair growth can be stimulated by combining certain skin cells, which can rejuvenate old cells and cause them to specialize in hair follicle creation.

research The Upper Dermal Sheath Has Potential to Regenerate Hair in Rat Follicular Epidermis

31 citations, September 1996 in “Differentiation”

The upper dermal sheath can regenerate hair in rats.

Related Community Posts Join

6 / 13 results

community Microneedling and aloe vera to recruit stem cells.

in Chat 11 upvotes 10 months ago

Microneedling combined with aloe vera may stimulate dormant stem cells in hair loss areas. Minoxidil is also suggested for better results.

community Lavdik Hair Growth Serum?

in Product 4 years ago

A user is concerned about the legitimacy of a hair growth serum called Lavdik, which they ordered after seeing an ad for Jemros. The product contains ginger extract, ginseng extract, fleece flower root, grape seed oil, glycerol, carbomer, propylene glycol, and rosemary oil, and the user is unsure if it is effective or a scam.

community The Real Cause Of Androgenetic Alopecia

in Research/Science 667 upvotes 2 months ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

community This guy claims stem cells fixed his balding

in Is this regrowth? 301 upvotes 1 year ago

A man who claimed to have regrown his hair using stem cell treatment, sparking a debate about its effectiveness and cost. Some users suggested he might be using other treatments or substances, while others shared their own experiences with stem cell therapy for hair loss.

community UPDATE: The theory that explains everything. Please help me make this big!

in Research/Science 449 upvotes 3 years ago

Hair loss theory involves 3alpha-hydroxysteroid reductase (3AHD) converting DHT to androstenol. Discussion explores potential treatments and encourages more research.

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 4 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

Related Research

6 / 6 results

research Possible Cellular Communication with Human Follicle Dermal Papilla Cells via Secretions from Human Hair Follicle Keratinocytes

January 2022 in “Journal of St. Marianna University”

Substances from human hair cells can affect hair loss-related genes, potentially leading to new treatments for baldness.

research A Model System to Analyze the Ability of Human Keratinocytes to Form Hair Follicles

15 citations, April 2014 in “Experimental Dermatology”

Scientists developed a system to study human hair growth using skin cells, which could help understand hair development and improve skin substitutes for medical use.

research Review of Hair Follicle Dermal Cells

321 citations, December 2009 in “Journal of Dermatological Science”

Dermal cells are key in controlling hair growth and could potentially be used in hair loss treatments, but more research is needed to improve hair regeneration methods.