Application of Mesenchymal Stem Cells Derived from Bone Marrow and Umbilical Cord in Human Hair Multiplication

September 2010 in “ Journal of dermatological science ”

Bo-Young Yoo, Youn-Ho Shin, Hee-Hoon Yoon, Young-Kwon Seo, Kye‐Yong Song, Jung-Keug Park

mesenchymal stem cells bone marrow umbilical cord alopecia hair multiplication dermal papilla-like tissues dermal papilla cells hair follicle formation hair cell therapy MSCs DPLTs

Studysummary This study suggests that mesenchymal stem cell-induced dermal papilla-like tissues can generate new hair follicles in mice, indicating potential for developing hair cell therapy using stem cells.

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The study investigated the potential of mesenchymal stem cells (MSCs) derived from human bone marrow and umbilical cord for treating alopecia by inducing hair multiplication. Researchers isolated and cultivated these MSCs to form dermal papilla-like tissues (DPLTs), which were tested in vitro and in vivo using athymic mice. The DPLTs exhibited similar characteristics to natural dermal papilla cells and successfully induced new hair follicle formation. The findings suggested that MSCs from bone marrow or umbilical cord could be promising sources for human hair cell therapy.

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This review discusses various approaches to treating alopecia, including drug therapy and hair transplantation, but reports no new research findings; the authors highlight the need for novel techniques like cell culturing.

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research Microencapsulated Human Hair Dermal Papilla Cells: A Substitute for Dermal Papilla?

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This study found that transplanted microencapsulated dermal papilla cells in rat footpads can regenerate hair follicles and sebaceous gland structures, suggesting a potential substitute for fresh dermal papillae cells.

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Mesenchymal cells can significantly boost human hair growth and longevity.

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research Biological Characterization of Cultured Dermal Papilla Cells and Hair Follicle Regeneration In Vitro and In Vivo

24 citations , February 2006 in “Chinese Medical Journal”

This study found that dermal papilla cells cultured in vitro can promote hair follicle regeneration and maintain hair growth, with stronger ET-1 and SCF expression enhancing this regenerative ability.

research Primary Cell Culture and Morphological Characterization of Canine Dermal Papilla Cells and Dermal Fibroblasts

32 citations , February 2002 in “Veterinary Dermatology”

This study reported that canine dermal papilla cells showed a distinct growth pattern and strong collagen IV and laminin staining compared to dermal fibroblasts.

research Histologic and Cell Kinetic Studies of Hair Loss and Subsequent Recovery Process of Human Scalp Hair Follicles Grafted onto Severe Combined Immunodeficient Mice

31 citations , August 2000 in “Journal of Investigative Dermatology”

This study found that when human hair follicles were grafted onto mice, they progressed through dystrophic stages and returned to normal growth, with stem cells aiding in recovery.

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61 citations , October 1996 in “Development”

This study found that combining adult germinative epidermal cells with non-inductive dermal cells can stimulate hair follicle neogenesis, effectively altering the cells' status to enhance induction.

research The Upper Dermal Sheath Has Potential to Regenerate Hair in Rat Follicular Epidermis

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This study claims that the upper dermal sheath of rat vibrissa follicles can induce hair growth under specific conditions, challenging prior beliefs about its lack of inductive capacity.

research Experimental Approaches for the Reconstitution of Hair In Vitro

6 citations , January 1994 in “Skin Pharmacology and Physiology”

This study suggests that the attachment and interaction between dermal papillae and the hair bulb matrix are crucial for normal hair follicle growth and development in vitro.

research Induction of Follicle Formation and Hair Growth by Vibrissa Dermal Papillae Implanted into Rat Ear Wounds: Vibrissa-Type Fibres Are Specified

125 citations , August 1992 in “Development”

This study found that implanting isolated adult rat dermal papillae into ear cuts led to the emergence of unusually large vibrissa-type hair follicles, demonstrating their capacity to induce specific hair fiber characteristics.