Hair Growth-Promoting Effects of Camellia Seed Cake Extract in Human Dermal Papilla Cells and C57BL/6 Mice

    April 2022 in “ Journal of Cosmetic Dermatology ”
    Jing Wang, Huchi Shen, Timson Chen, Ling Ma
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    TLDR Camellia seed cake extract helps hair grow by affecting cell growth and growth factor levels.
    The study "Hair growth‐promoting effects of Camellia seed cake extract in human dermal papilla cells and C57BL/6 mice" investigated the effects of de-saponinated Camellia seed cake extracts (DS-CSE) on hair growth. The research was conducted using both in vitro and in vivo models. The results showed that DS-CSE treatment significantly proliferated human dermal papilla cells (DPCs), increased the proportion of DPCs in S and G2/M phases, activated potassium channels, and promoted the phosphorylation of ERK and AKT in DPCs. DS-CSE treatment also significantly upregulated the mRNA levels of hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF), and insulin-like growth factor-1 (IGF-1), and downregulated the mRNA level of transforming growth factor-β (TGF-β1). Topical application of DS-CSE promoted hair growth on shaven back mice and also upregulated the expression of VEGF in mice. The study concluded that DS-CSE promotes hair growth in vitro and in vivo by proliferating DPCs through the ERK and AKT signaling pathways and regulating the expression of growth factors.
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