Naturally Occurring Hair Growth Peptide: Water-Soluble Chicken Egg Yolk Peptides Stimulate Hair Growth Through Induction of Vascular Endothelial Growth Factor Production

March 2018 in “ Journal of Medicinal Food ”

Toshio Nakamura, Hisao Yamamura, Kyungho Park, Caroline Pereira, Yoshikazu Uchida, Nobutaka Horie, Mujo Kim, Satoshi Itami

hair growth peptide HGP Vascular Endothelial Growth Factor VEGF human hair follicle dermal papilla cells female pattern hair loss FPHL insulin growth factor-1 receptor hypoxia-inducible factor-1 pathway minoxidil human hair follicle cells IGF-1 receptor HIF-1 pathway Rogaine

TLDR Chicken egg yolk peptides can promote hair growth by increasing a specific growth factor.

In the 2018 study by Nakamura et al., researchers found that water-soluble peptides from chicken egg yolk, named "hair growth peptide" (HGP), could stimulate hair growth by inducing Vascular Endothelial Growth Factor (VEGF) production. The study showed that HGP increased VEGF production, promoted human hair follicle dermal papilla cells proliferation, and enhanced hair growth in mouse models and 76 human subjects with female pattern hair loss (FPHL) over 24 weeks. The peptides activated VEGF expression through the insulin growth factor-1 receptor and the hypoxia-inducible factor-1 pathway. HGP was suggested as a safe alternative to minoxidil, without the associated side effects. The human clinical trial results were based on 35 subjects after excluding 2 for significant changes in hair growth rate and density.

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