Naturally Occurring Hair Growth Peptide: Water-Soluble Chicken Egg Yolk Peptides Stimulate Hair Growth Through Induction of Vascular Endothelial Growth Factor Production

March 2018 in “ Journal of Medicinal Food ”

Toshio Nakamura, Hisao Yamamura, Kyungho Park, Caroline Pereira, Yoshikazu Uchida, Nobutaka Horie, Mujo Kim, Satoshi Itami

hair growth peptide HGP Vascular Endothelial Growth Factor VEGF human hair follicle dermal papilla cells female pattern hair loss FPHL insulin growth factor-1 receptor hypoxia-inducible factor-1 pathway minoxidil human hair follicle cells IGF-1 receptor HIF-1 pathway Rogaine

TLDR Chicken egg yolk peptides can promote hair growth by increasing a specific growth factor.

In the 2018 study by Nakamura et al., researchers found that water-soluble peptides from chicken egg yolk, named "hair growth peptide" (HGP), could stimulate hair growth by inducing Vascular Endothelial Growth Factor (VEGF) production. The study showed that HGP increased VEGF production, promoted human hair follicle dermal papilla cells proliferation, and enhanced hair growth in mouse models and 76 human subjects with female pattern hair loss (FPHL) over 24 weeks. The peptides activated VEGF expression through the insulin growth factor-1 receptor and the hypoxia-inducible factor-1 pathway. HGP was suggested as a safe alternative to minoxidil, without the associated side effects. The human clinical trial results were based on 35 subjects after excluding 2 for significant changes in hair growth rate and density.

View this study on liebertpub.com →

Discuss this study in the Community →

Research cited in this study

11 / 11 results

research Androgenetic Alopecia: An Update Of Treatment Options

110 citations, August 2016 in “Drugs”

Minoxidil is the only FDA-approved topical drug for treating male or female pattern hair loss, and other medications like finasteride and dutasteride can also increase hair growth.

research Contribution of Hair Density and Hair Diameter to the Appearance and Progression of Androgenetic Alopecia in Japanese Men

21 citations, July 2014 in “British Journal of Dermatology”

Hair thickness matters more than density for baldness in Japanese men over 25.

research Cow Placenta Extract Promotes Murine Hair Growth Through Enhancing the Insulin-Like Growth Factor-1

22 citations, January 2011 in “Indian Journal of Dermatology/Indian journal of dermatology”

Cow placenta extract may help hair grow by increasing a growth factor but is less effective than minoxidil.

research Adenosine Stimulates Fibroblast Growth Factor-7 Gene Expression Via Adenosine A2b Receptor Signaling in Dermal Papilla Cells

66 citations, February 2007 in “The journal of investigative dermatology/Journal of investigative dermatology”

Adenosine may promote hair growth by increasing FGF-7 levels in dermal papilla cells.

research Prevalence of Male and Female Pattern Hair Loss in Maryborough

193 citations, August 2005 in “Journal of Investigative Dermatology Symposium Proceedings”

Hair loss common in Australia; men affected earlier, more often than Asians; women less concerned.

research A Randomized, Placebo-Controlled Trial of 5% and 2% Topical Minoxidil Solutions in the Treatment of Female Pattern Hair Loss

219 citations, March 2004 in “Journal of The American Academy of Dermatology”

5% and 2% minoxidil solutions effectively promote hair growth and reduce hair loss, with 5% being slightly more effective but having more side effects.

Minoxidil-Induced Hair Growth Is Mediated by Adenosine in Cultured Dermal Papilla Cells: Possible Involvement of Sulfonylurea Receptor 2B as a Target of Minoxidil

research Minoxidil-Induced Hair Growth Is Mediated by Adenosine in Cultured Dermal Papilla Cells: Possible Involvement of Sulfonylurea Receptor 2B as a Target of Minoxidil

83 citations, December 2001 in “Journal of Investigative Dermatology”

Minoxidil boosts hair growth by targeting adenosine and possibly sulfonylurea receptor 2B.

research Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis

520 citations, February 2001 in “Journal of Clinical Investigation”

VEGF helps hair grow and determines follicle size by increasing blood vessel growth.

research Lack of Efficacy of Finasteride in Postmenopausal Women with Androgenetic Alopecia

239 citations, November 2000 in “Journal of The American Academy of Dermatology”

Finasteride doesn't effectively treat hair loss in postmenopausal women.

research The Midline Part: An Important Physical Clue to the Clinical Diagnosis of Androgenetic Alopecia in Women

90 citations, January 1999 in “Journal of The American Academy of Dermatology”

"Christmas tree" pattern helps diagnose female hair loss.

research Long-Term Efficacy of Topical Minoxidil in Male Pattern Baldness

41 citations, March 1987 in “Journal of The American Academy of Dermatology”

Topical minoxidil effectively treats male pattern baldness and prevents hair loss.

Related Research

9 / 9 results

research 3D Spheroid Human Dermal Papilla Cell as an Effective Model for the Screening of Hair Growth Promoting Compounds: Examples of Minoxidil and 3,4,5-Tri-O-Caffeoylquinic Acid (TCQA)

2 citations, June 2022 in “Cells”

3D cell cultures are better for testing hair growth treatments than 2D cultures.

Establishment of 3D Spheroid Human Dermal Papilla Cells as an Effective Model for Hair Growth Screening Compounds Compared with the 2D System: An Example of Minoxidil and 3,4,5-Tri-O-Caffeoylquinic Acid

research Establishment of 3D Spheroid Human Dermal Papilla Cells as an Effective Model for Hair Growth Screening Compounds Compared with the 2D System: An Example of Minoxidil and 3,4,5-Tri-O-Caffeoylquinic Acid

November 2021 in “Research Square (Research Square)”

3D spheroid cultures of human hair follicle cells are better for hair growth research than 2D cultures, and they provide new insights into how hair growth treatments like minoxidil and TCQA work.

research Pharmacopuncture and Dermal Application of Sebalgukhwa-San: Effects on Hair Growth in a Mouse Model of Alopecia

May 2019 in “Journal of Acupuncture Research”

Sebalgukhwa-san (SGS) can help treat hair loss without liver toxicity.

Naturally Occurring Hair Growth Peptide: Water-Soluble Chicken Egg Yolk Peptides Stimulate Hair Growth Through Induction of Vascular Endothelial Growth Factor Production

research Naturally Occurring Hair Growth Peptide: Water-Soluble Chicken Egg Yolk Peptides Stimulate Hair Growth Through Induction of Vascular Endothelial Growth Factor Production

6 citations, March 2018 in “Journal of Medicinal Food”

Chicken egg yolk peptides can promote hair growth by increasing a specific growth factor.

research Hair Physiology: Hair Growth, Alopecia, Scalp Treatment, Etc.

1 citations, January 2017 in “Elsevier eBooks”

The document concludes that new treatments for hair loss may involve a combination of cosmetics, clinical methods, and genetic approaches.

research Hematological And Hepatic Effects Of Vascular Epidermal Growth Factor (VEGF) Used To Stimulate Hair Growth In An Animal Model

30 citations, October 2013 in “BMC dermatology”

VEGF gel increases hair growth but may have potential toxicity.

Naturally Occurring Hair Growth Peptide: Water-Soluble Chicken Egg Yolk Peptides Stimulate Hair Growth Through Induction of Vascular Endothelial Growth Factor Production

Research cited in this study

research Androgenetic Alopecia: An Update Of Treatment Options

research Contribution of Hair Density and Hair Diameter to the Appearance and Progression of Androgenetic Alopecia in Japanese Men

research Cow Placenta Extract Promotes Murine Hair Growth Through Enhancing the Insulin-Like Growth Factor-1

research Adenosine Stimulates Fibroblast Growth Factor-7 Gene Expression Via Adenosine A2b Receptor Signaling in Dermal Papilla Cells

research Prevalence of Male and Female Pattern Hair Loss in Maryborough

research A Randomized, Placebo-Controlled Trial of 5% and 2% Topical Minoxidil Solutions in the Treatment of Female Pattern Hair Loss

research Minoxidil-Induced Hair Growth Is Mediated by Adenosine in Cultured Dermal Papilla Cells: Possible Involvement of Sulfonylurea Receptor 2B as a Target of Minoxidil

research Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis

research Lack of Efficacy of Finasteride in Postmenopausal Women with Androgenetic Alopecia

research The Midline Part: An Important Physical Clue to the Clinical Diagnosis of Androgenetic Alopecia in Women

research Long-Term Efficacy of Topical Minoxidil in Male Pattern Baldness

Related Community Posts Join

community Coegin Pharma to release Follicopeptide (FOL005) by Q2 2025

community Peptides that Stop Hair Loss? | In-depth Literature Review Video

community Does it work? Maneup GHK-Cu hair growth serum

community Anyone ever try peptides for hair growth?

community Herbacle hair growth serum with 0% min

community Recommended AHK-Cu peptide brand?

Related Research

research 3D Spheroid Human Dermal Papilla Cell as an Effective Model for the Screening of Hair Growth Promoting Compounds: Examples of Minoxidil and 3,4,5-Tri-O-Caffeoylquinic Acid (TCQA)

research Establishment of 3D Spheroid Human Dermal Papilla Cells as an Effective Model for Hair Growth Screening Compounds Compared with the 2D System: An Example of Minoxidil and 3,4,5-Tri-O-Caffeoylquinic Acid

research Pharmacopuncture and Dermal Application of Sebalgukhwa-San: Effects on Hair Growth in a Mouse Model of Alopecia

research Naturally Occurring Hair Growth Peptide: Water-Soluble Chicken Egg Yolk Peptides Stimulate Hair Growth Through Induction of Vascular Endothelial Growth Factor Production

research Hair Physiology: Hair Growth, Alopecia, Scalp Treatment, Etc.

research Hematological And Hepatic Effects Of Vascular Epidermal Growth Factor (VEGF) Used To Stimulate Hair Growth In An Animal Model

research Cow Placenta Extract Promotes Murine Hair Growth Through Enhancing the Insulin-Like Growth Factor-1

research Minoxidil Upregulates the Expression of Vascular Endothelial Growth Factor in Human Hair Dermal Papilla Cells

research Hair Follicle Biology and Topical Minoxidil: Possible Mechanisms of Action