Pharmacopuncture and Dermal Application of Sebalgukhwa-San: Effects on Hair Growth in a Mouse Model of Alopecia

    Meiling Ji, Seong Chul Lim, Jae Soo Kim, Hyun Jong Lee, Yun Kyu Lee
    TLDR Sebalgukhwa-san (SGS) can help treat hair loss without liver toxicity.
    The study evaluated the effects of pharmacopuncture and dermal application of Sebalgukhwa-san (SGS) on hair growth in a mouse model of alopecia, involving 21 C57BL/6 mice divided into control, minoxidil (MNXD), and SGS groups. Both MNXD and SGS treatments significantly improved hair density, thickness, and the number of hair follicles compared to the control group. Protein expression related to hair growth increased, while liver function tests showed no significant toxicity. The findings suggested that Sebalgukhwa-san could be a promising and safer alternative for treating alopecia, though further studies are needed to confirm its safety and efficacy in clinical settings.
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