VEGF165 Modulates Proliferation, Adhesion, Migration, and Differentiation of Cultured Human Outer Root Sheath Cells from Central Hair Follicle Epithelium Through VEGFR-2 Activation In Vitro

October 2013 in “ Journal of Dermatological Science ”

Xianjie Wu, Jian-Wei Zhu, Jing Jing, Dan Xue, Hai Liu, Min Zheng, Zhongfa Lu

VEGF165 VEGFR-2 outer root sheath cells hair follicle epithelium integrin β1 lgr6 phosphorylation Erk1/2 c-Jun p38 VEGFR-2 neutralizing antibody vascular endothelial growth factor vascular endothelial growth factor receptor 2

Studysummary This study observed that VEGF165 increases proliferation and migration but alters adhesion properties of cultured human hair follicle cells, indicating a potential role for VEGF/VEGFR-2 in hair follicle regulation beyond angiogenesis.

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The study explored the effects of VEGF165 and VEGFR-2 on human outer root sheath cells from the central hair follicle epithelium, revealing that VEGFR-2 was present in these cells both in vivo and in vitro. VEGF165 was found to enhance cell proliferation and migration, reduce homotypic adhesion, and increase heterotypic adhesion. It also upregulated integrin β1 and downregulated lgr6 expression, while promoting phosphorylation of VEGFR-2, Erk1/2, c-Jun, and p38. These effects were reversed by a VEGFR-2 neutralizing antibody, indicating that VEGF/VEGFR-2 had a significant role in hair follicle regulation beyond its known function in angiogenesis.

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Research cited in this study

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VEGF165 Modulates Proliferation, Adhesion, Migration, and Differentiation of Cultured Human Outer Root Sheath Cells from Central Hair Follicle Epithelium Through VEGFR-2 Activation In Vitro

Research cited in this study

research VEGF Upregulates VEGF Receptor-2 on Human Outer Root Sheath Cells and Stimulates Proliferation Through ERK Pathway

research VEGF Induces Proliferation of Human Hair Follicle Dermal Papilla Cells Through VEGFR-2-Mediated Activation of ERK

research The Hair Follicle Bulge: A Niche for Adult Stem Cells

research In Vitro Differences Between Keratinocyte Stem Cells and Transit-Amplifying Cells of the Human Hair Follicle

research Expression of Vascular Endothelial Growth Factor, Apoptosis Inhibitors (Survivin and p16) and CCL27 in Alopecia Areata Before and After Diphencyprone Treatment: An Immunohistochemical Study

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