3D Spheroid Human Dermal Papilla Cell as an Effective Model for the Screening of Hair Growth Promoting Compounds: Examples of Minoxidil and 3,4,5-Tri-O-Caffeoylquinic Acid (TCQA)
June 2022
in “
Cells
”
3D spheroid cultures human dermal papilla cells DPCs hair growth-promoting compounds minoxidil 3,4,5-Tri-O-Caffeoylquinic Acid TCQA cell-cell interactions cell-ECM interactions hair growth-associated genes cell adhesion collagen production inflammation cell division 3D cultures dermal papilla cells hair growth compounds Rogaine chlorogenic acid cell interactions extracellular matrix interactions hair growth genes collagen
Studysummary The study found that growing dermal papilla cells in 3D spheroids enhances their activity with hair growth-promoting agents, such as minoxidil and TCQA, compared to traditional 2D cultures.
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