Application of Mesenchymal Stem Cells for Anti-Senescence and Clinical Challenges

September 2023 in “ Stem cell research & therapy ”

Yaping Wang, Tingting Gao, Bin Wang

mesenchymal stem cells MSCs senescence paracrine action immunoregulatory effects

TLDR Mesenchymal stem cells could help treat aging-related diseases better than current methods.

The document reviews the application of mesenchymal stem cells (MSCs) in combating cellular senescence and addressing clinical challenges. MSCs show promise in treating age-related diseases like Alzheimer's, Parkinson's, cardiovascular diseases, osteoporosis, and hair loss due to their regenerative properties, ability to modulate immune responses, and reduce oxidative stress. Studies indicate MSCs can promote hair follicle regeneration, improve skin conditions, and enhance bone formation. However, challenges such as ensuring safety, efficacy, and long-term stability of MSC-based treatments remain, necessitating further research and clinical trials.

View this study on stemcellres.biomedcentral.com →

Discuss this study in the Community →

Cited in this study

12 / 12 results

research Regenerative Medicine Strategies for Hair Growth and Regeneration: A Narrative Review of Literature

8 citations , December 2022 in “Regenerative Therapy”

New regenerative treatments for hair loss show promise but need more research for confirmation.

research Hair Follicle-Derived Mesenchymal Stem Cells Decrease Alopecia Areata Mouse Hair Loss and Reduce Inflammation Around the Hair Follicle

11 citations , October 2021 in “Stem Cell Research & Therapy”

Hair follicle stem cells reduced hair loss and inflammation in mice with a condition similar to human alopecia.

research TMT-Based Quantitative Proteomic Analysis Reveals the Effect of Bone Marrow Derived Mesenchymal Stem Cells on Hair Follicle Regeneration

4 citations , June 2021 in “Frontiers in Pharmacology”

research Applications of Mesenchymal Stem Cells in Skin Regeneration and Rejuvenation

76 citations , February 2021 in “International Journal of Molecular Sciences”

Mesenchymal stem cells show potential for skin healing and anti-aging, but more research is needed for safe use, especially regarding stem cells from induced pluripotent sources.

research Premature Aging Syndromes: From Patients to Mechanism

29 citations , November 2019 in “Journal of dermatological science”

Studying premature aging syndromes helps understand human aging and suggests potential treatments.

research Overexpression of Nanog in Amniotic Fluid-Derived Mesenchymal Stem Cells Accelerates Dermal Papilla Cell Activity and Promotes Hair Follicle Regeneration

14 citations , July 2019 in “Experimental and Molecular Medicine”

Nanog gene boosts stem cells, helps hair growth, and may treat hair loss.

research Dental Derived Stem Cell Conditioned Media for Hair Growth Stimulation

15 citations , May 2019 in “PLOS ONE”

Substances from dental stem cells might help treat hair loss.

research The Dynamics of the Skin’s Immune System

306 citations , April 2019 in “International Journal of Molecular Sciences”

The skin has a complex immune system that is essential for protection and healing, requiring more research for better wound treatment.

research A Therapeutic Microneedle Patch Made from Hair-Derived Keratin for Promoting Hair Regrowth

192 citations , April 2019 in “ACS nano”

A new microneedle patch made from hair proteins helps regrow hair faster and better than current treatments.

research Extracellular Vesicles Derived from MSCs Activate Dermal Papilla Cells In Vitro and Promote Hair Follicle Conversion from Telogen to Anagen in Mice

113 citations , November 2017 in “Scientific Reports”

Tiny particles from stem cells help activate hair growth cells and encourage hair growth in mice without being toxic.

research Defining Dermal Adipose Tissue

218 citations , September 2014 in “Experimental Dermatology”

Skin fat cells help with skin balance, hair growth, and healing wounds.

research Emerging Interactions Between Skin Stem Cells and Their Niches

426 citations , August 2014 in “Nature Medicine”

Skin stem cells interacting with their environment is crucial for maintaining and regenerating skin and hair, and understanding this can help develop new treatments for skin and hair disorders.