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Glossary Paracrine Function

cells communicate by releasing signals to nearby cells

Paracrine function refers to a type of cell signaling where a cell produces a signal to induce changes in nearby cells, affecting their behavior or function. Unlike hormones that travel through the bloodstream to distant targets, paracrine signals act locally, ensuring that the response is limited to the immediate cellular environment. This is crucial in processes like wound healing and immune responses.

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research Mechanism of action to accelerate second deep degree scald wound healing by endogenous EGF

2 citations , January 2001 in “Medical Journal of National Defending Forces in Northwest China”

This study found that endogenous EGF may facilitate the healing of second-degree scald wounds in mice through autocrine, paracrine, and endocrine mechanisms.

research Androgens and androgen receptor action in skin and hair follicles

100 citations , September 2017 in “Molecular and Cellular Endocrinology”

This review discusses the molecular mechanisms of androgens and androgen receptors in skin disorders, particularly androgenetic alopecia, and reports no new clinical results; it highlights potential areas for future treatment development.

research Melatonin membrane receptors in peripheral tissues: Distribution and functions

506 citations , January 2012 in “Molecular and Cellular Endocrinology”

This review details the expression and diverse functions of melatonin receptors in non-neural tissues and reports no new clinical findings, emphasizing their potential as therapeutic targets across various physiological and pathological processes.

research Biomaterials Functionalized with MSC Secreted Extracellular Vesicles and Soluble Factors for Tissue Regeneration

220 citations , March 2020 in “Advanced functional materials”

This review discusses the mechanisms and potential therapeutic benefits of mesenchymal stromal cell-derived extracellular vesicles delivered via biomaterials, but reports no new clinical results.

research Multipotent adult progenitor cells grown under xenobiotic-free conditions support vascularization during wound healing

4 citations , September 2020 in “Stem Cell Research & Therapy”

In this study, xenobiotic-free human multipotent adult progenitor cells were found to improve wound vascularization and healing in mice, suggesting potential applicability for clinical use in humans.

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community Creatine is the opposite of minoxidil !

324 upvotes 10 months ago

Creatine may counteract minoxidil's hair growth effects by closing potassium ATP channels, potentially leading to hair loss in predisposed individuals. Despite anecdotal reports, there is no conclusive evidence linking creatine to hair loss.

community How come topical finasteride even works at all?

in Finasteride/Dutasteride 29 upvotes 10 months ago

Topical finasteride can effectively reduce scalp DHT by targeting local enzymes, despite less systemic impact compared to oral forms. Combining oral dutasteride with topical finasteride and minoxidil may enhance hair loss prevention, though evidence of its effectiveness is limited.

community Efficacy and Tolerability of N-Acetyl-Cysteine for Treatment of The Early-onset Androgenetic Alopecia in Men

26 upvotes 4 years ago

N-Acetyl-Cysteine (NAC) was found to improve hair parameters in men with early-onset androgenetic alopecia, showing increased terminal hair count and decreased vellus hair count, with good tolerability. NAC, used alone or with minoxidil, may help due to its antioxidant properties, though its effectiveness can vary among individuals.

community Is 2.5 mg of dut even worth it?

in Finasteride/Dutasteride 28 upvotes 1 year ago

Higher doses of dutasteride, like 2.5 mg, may offer more hair growth than 0.5 mg, but the difference is not significant for most people. Many users find 0.5 mg effective, and increasing the dose is often unnecessary unless experiencing severe hair loss.

community The mechanism of androgenic alopecia

36 upvotes 11 months ago

DHT may inhibit hair growth by affecting mitochondrial function, leading to hair follicle miniaturization. Treatments like minoxidil and PP405 may promote hair growth by altering metabolic pathways, potentially counteracting DHT's effects.

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learn Stem Cell Factor

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