Protective Effects of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Against Dexamethasone-Induced Apoptotic Cell Death in Hair Follicles

December 2019 in “ International Journal of Molecular Medicine ”

Dong Ho Bak, Esther Lee, Mi Sun Choi, Byung Mu Lee, Tae‐Rin Kwon, Jong Hwan Kim, Eun Jung Jeon, Wonil Oh, Seog‐Kyun Mun, Byung Park, Jungtae Na, Beom Kim

human umbilical cord blood-derived mesenchymal stem cells hUCB-MSCs dexamethasone hair follicles hair loss dermal papilla cells HaCaT cells vascular endothelial growth factor VEGF DKK-1 glucocorticoid stress autophagic flux stem cells glucocorticoid

TLDR Stem cells from umbilical cord blood may prevent hair loss caused by certain medications.

The study investigated the effects of human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) on hair loss, specifically focusing on their protective role against dexamethasone-induced hair follicle damage. In vivo experiments using a mouse model showed that hUCB-MSCs significantly prevented hair regression caused by dexamethasone. In vitro, these stem cells increased the proliferation of human dermal papilla cells and HaCaT cells, essential components of hair follicles, and stimulated vascular endothelial growth factor secretion while reducing DKK-1 expression. The study concluded that hUCB-MSCs could protect against glucocorticoid stress-related hair loss by enhancing cell viability, exhibiting anti-apoptotic effects, and regulating autophagic flux recovery, suggesting their potential as a therapeutic agent for preventing hair loss.

View this study on spandidos-publications.com →

Discuss this study in the Community →

Research cited in this study

14 / 14 results

research Autophagy Is Essential for Maintaining the Growth of a Human Mini-Organ: Evidence from Scalp Hair Follicle Organ Culture

42 citations , March 2018 in “PLOS Biology”

Autophagy is important for human hair growth and health.

research Androgen Modulation of Wnt/β-Catenin Signaling in Androgenetic Alopecia

39 citations , March 2018 in “Archives of Dermatological Research”

Androgens may block hair growth signals, targeting this could treat hair loss.

research Activation of Beta-Catenin Signaling in CD133-Positive Dermal Papilla Cells Drives Postnatal Hair Growth

26 citations , July 2016 in “PLOS ONE”

Activating β-catenin in certain skin cells speeds up hair growth in mice.

research Bee Venom Promotes Hair Growth by Inhibiting 5α-Reductase Expression

15 citations , January 2016 in “Biological & Pharmaceutical Bulletin”

Bee venom helps hair grow and may work better than some common treatments.

research Clinical Use of Conditioned Media of Adipose Tissue-Derived Stem Cells in Female Pattern Hair Loss: A Retrospective Case Series Study

83 citations , March 2015 in “International Journal of Dermatology”

ADSC-CM treatment improved hair density and thickness in women with hair loss, safely and effectively.

research Mesenchymal–Epithelial Interactions During Hair Follicle Morphogenesis and Cycling

300 citations , August 2012 in “Seminars in Cell & Developmental Biology”

The conclusion is that certain cell interactions and signals are crucial for hair growth and regeneration.

research Application of Mesenchymal Stem Cells Derived from Bone Marrow and Umbilical Cord in Human Hair Multiplication

41 citations , September 2010 in “Journal of dermatological science”

Bone marrow and umbilical cord stem cells can help grow new hair.

Self-Assembly of Dermal Papilla Cells into Inductive Spheroidal Microtissues on Poly(Ethylene-Co-Vinyl Alcohol) Membranes for Hair Follicle Regeneration

research Self-Assembly of Dermal Papilla Cells into Inductive Spheroidal Microtissues on Poly(Ethylene-Co-Vinyl Alcohol) Membranes for Hair Follicle Regeneration

80 citations , June 2008 in “Biomaterials”

EVAL membranes help create cell structures that can regrow hair follicles.

research Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding

829 citations , May 2007 in “Nature”

Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.

research Human Hair Follicles Display a Functional Equivalent of the Hypothalamic-Pituitary-Adrenal (HPA) Axis and Synthesize Cortisol

489 citations , June 2005 in “The FASEB Journal”

Human hair follicles can produce cortisol like the body's stress response system.

research Genetic Variation in the Human Androgen Receptor Gene Is the Major Determinant of Common Early-Onset Androgenetic Alopecia

195 citations , June 2005 in “American Journal of Human Genetics”

Genetic variation in the androgen receptor gene mainly causes early-onset hair loss, with maternal inheritance playing a key role.

Indications for a Brain-Hair Follicle Axis: Inhibition of Keratinocyte Proliferation and Up-Regulation of Keratinocyte Apoptosis in Telogen Hair Follicles by Stress and Substance P

research Indications for a Brain-Hair Follicle Axis: Inhibition of Keratinocyte Proliferation and Up-Regulation of Keratinocyte Apoptosis in Telogen Hair Follicles by Stress and Substance P

125 citations , September 2001 in “The FASEB Journal”

Stress can cause hair loss by negatively affecting hair follicles and this effect might be reversed with specific treatments.

research Minoxidil Upregulates the Expression of Vascular Endothelial Growth Factor in Human Hair Dermal Papilla Cells

192 citations , March 1998 in “British Journal of Dermatology”

Minoxidil boosts growth factor in hair cells, potentially promoting hair growth.

research A Murine Model for Inducing and Manipulating Hair Follicle Regression: Effects of Dexamethasone and Cyclosporin A

124 citations , August 1994 in “Journal of Investigative Dermatology”

Dexamethasone speeds up hair loss in mice, while cyclosporin A slows it down.

Related Research

2 / 2 results

research Pathobiology of Chemotherapy-Induced Hair Loss

218 citations , January 2013 in “The Lancet Oncology”

Chemotherapy causes hair loss by damaging hair follicles and stem cells, with more research needed for prevention and treatment.

research Towards a Molecular Understanding of Hair Loss and Its Treatment

236 citations , July 2001 in “Trends in Molecular Medicine”

Future hair loss treatments should aim to extend hair growth, reactivate resting follicles, reverse shrinkage, and possibly create new follicles, with gene therapy showing promise.