Protective Effects of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Against Dexamethasone-Induced Apoptotic Cell Death in Hair Follicles

December 2019 in “ International Journal of Molecular Medicine ”

Dong Ho Bak, Esther Lee, Mi Sun Choi, Byung Mu Lee, Tae‐Rin Kwon, Jong Hwan Kim, Eun Jung Jeon, Wonil Oh, Seog‐Kyun Mun, Byung Park, Jungtae Na, Beom Kim

human umbilical cord blood-derived mesenchymal stem cells hUCB-MSCs dexamethasone hair follicles hair loss dermal papilla cells HaCaT cells vascular endothelial growth factor VEGF DKK-1 glucocorticoid stress autophagic flux stem cells glucocorticoid

Studysummary This study found that human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) significantly prevented hair loss induced by dexamethasone in a mouse model and enhanced cell proliferation in human hair follicle cells, suggesting a protective effect against stress-related hair loss.

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The study investigated the effects of human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) on hair loss, specifically focusing on their protective role against dexamethasone-induced hair follicle damage. In vivo experiments using a mouse model showed that hUCB-MSCs significantly prevented hair regression caused by dexamethasone. In vitro, these stem cells increased the proliferation of human dermal papilla cells and HaCaT cells, essential components of hair follicles, and stimulated vascular endothelial growth factor secretion while reducing DKK-1 expression. The study concluded that hUCB-MSCs could protect against glucocorticoid stress-related hair loss by enhancing cell viability, exhibiting anti-apoptotic effects, and regulating autophagic flux recovery, suggesting their potential as a therapeutic agent for preventing hair loss.

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