Regenerative Medicine Strategies for Hair Growth and Regeneration: A Narrative Review of Literature

    December 2022 in “Regenerative Therapy
    Yusuke Shimizu, Edward H. Ntege, Hiroshi Sunami, Yoshikazu Inoue
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    TLDR New regenerative treatments for hair loss show promise but need more research for confirmation.
    The document reviews regenerative medicine strategies for treating alopecia, focusing on mesenchymal stem cell (MSC) implantation, MSC-derived secretome treatment, and platelet-rich plasma therapies. Conventional treatments like corticosteroids, minoxidil, and 5α-reductase inhibitors have significant side effects and limited efficacy, necessitating novel therapies. MSCs suppress inflammation and modulate immune responses, beneficial for conditions like alopecia. Adipose-derived MSCs (AD-MSCs) have shown promising results, increasing hair diameter and density in 19 out of 20 patients within 3-6 months of treatment. Other cell types like bone marrow-derived MSCs (BM-MSCs), human umbilical cord blood-derived MSCs (hUCB-MSCs), human dermal papilla cells (hDPCs), and human induced pluripotent stem cells (hiPSCs) have also shown potential. Cell-free therapies, including MSC-derived extracellular vesicles (EVs) and exosomes, are being explored for hair growth and regeneration. Despite promising results, larger, more controlled clinical trials with standardized protocols are needed.
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