New Insight Into the Pathophysiology of Hair Loss Trigger a Paradigm Shift in the Treatment Approach

November 2017 in “ PubMed ”

Neil S. Sadick, Valerie D. Callender, Leon Kircik, Sophia Kogan

hair loss androgenetic alopecia follicle physiology inflammatory component pathogenesis intrinsic signaling pathways AGA

TLDR New research suggests treating hair loss should focus on common inflammation rather than individual molecules.

The review from November 1, 2017, titled "New Insight Into the Pathophysiology of Hair Loss Trigger a Paradigm Shift in the Treatment Approach" discussed the impact of hair loss on millions of men and women of all ages and ethnicities. The available treatment options were limited and carried potential side effects, with none proving to be comprehensive for hair loss treatment. The main trend in therapeutics was to focus on targeting single molecules or pathways. However, research indicated similar dysregulation of intrinsic signaling pathways within follicle physiology across the spectrum of hair loss disorders. A common inflammatory component was identified in most hair loss pathogenesis, including androgenetic alopecia (AGA).

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