The Rise of Induced Pluripotent Stem Cell Approach to Hair Restoration

    November 2021 in “ Plastic and Reconstructive Surgery ”
    Antonella Pinto, Alexey V. Terskikh
    Studysummary This article reviews the potential of using induced pluripotent stem cells for hair restoration, underscoring their promise over current surgical methods, but reports no new clinical results.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on journals.lww.com →
    Discuss this study in the Community →

    Research cited in this study 24

    1. Hair-Bearing Human Skin Generated Entirely From Pluripotent Stem Cells Nature · 2020
    2. Functional Complexity of Hair Follicle Stem Cell Niche and Therapeutic Targeting of Niche Dysfunction for Hair Regeneration Journal of Biomedical Science · 2020
    3. Tissue Engineering Strategies for Human Hair Follicle Regeneration: How Far From a Hairy Goal? Stem Cells Translational Medicine · 2019
    4. Feasibility of Repairing Full-Thickness Skin Defects by iPSC-Derived Epithelial Stem Cells Seeded on a Human Acellular Amniotic Membrane Stem cell research & therapy · 2019
    5. Tissue Engineering of Human Hair Follicles Using a Biomimetic Developmental Approach Nature Communications · 2018
    6. Review of Human Hair Follicle Biology: Dynamics of Niches and Stem Cell Regulation for Possible Therapeutic Hair Stimulation for Plastic Surgeons Aesthetic Plastic Surgery · 2018
    7. Hair Follicle Development in Mouse Pluripotent Stem Cell-Derived Skin Organoids Cell Reports · 2018
    8. Induction of Hair Follicle Dermal Papilla Cell Properties in Human Induced Pluripotent Stem Cell-Derived Multipotent LNGFR(+)THY-1(+) Mesenchymal Cells Scientific Reports · 2017
    9. Genetic Prediction of Male Pattern Baldness PLoS Genetics · 2017
    10. Hunting the Genes in Male-Pattern Alopecia: How Important Are They, How Close Are We and What Will They Tell Us? Experimental Dermatology · 2016
    11. Generation of Folliculogenic Human Epithelial Stem Cells from Induced Pluripotent Stem Cells Nature communications · 2014
    12. Microenvironmental Reprogramming by Three-Dimensional Culture Enables Dermal Papilla Cells to Induce De Novo Human Hair-Follicle Growth Proceedings of the National Academy of Sciences of the United States of America · 2013
    13. Mesenchymal–Epithelial Interactions During Hair Follicle Morphogenesis and Cycling Seminars in Cell & Developmental Biology · 2012
    14. Fully Functional Hair Follicle Regeneration Through the Rearrangement of Stem Cells and Their Niches Nature Communications · 2012
    15. Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration Cell · 2011
    16. Hair Follicle Stem Cells Provide a Functional Niche for Melanocyte Stem Cells Cell stem cell · 2011
    17. Hair Follicle Neogenesis Induced by Cultured Human Scalp Dermal Papilla Cells Regenerative Medicine · 2009
    18. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    19. Differences in Expression of Specific Biomarkers Distinguish Human Beard from Scalp Dermal Papilla Cells Journal of Investigative Dermatology · 2006
    20. Comparative Characterization of Hair Follicle Dermal Stem Cells and Bone Marrow Mesenchymal Stem Cells Stem Cells and Development · 2006
    21. Molecular Dissection of Mesenchymal–Epithelial Interactions in the Hair Follicle PLoS biology · 2005
    22. Organogenesis From Dissociated Cells: Generation of Mature Cycling Hair Follicles From Skin-Derived Cells Journal of Investigative Dermatology · 2005
    23. Hair Follicle Pigmentation: Mechanisms and Factors Influencing Melanin Production ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2005
    24. The Biology of Hair Follicles The New England Journal of Medicine · 1999

    Related research 5

    1. Electrical Stimulation to Human Dermal Papilla Cells for Hair Regenerative Medicine Journal of Bioscience and Bioengineering · 2022
    2. Induced Pluripotent Stem Cell Approach to Hair Follicle Regeneration Stem cell biology and regenerative medicine · 2022
    3. The Rise of Induced Pluripotent Stem Cell Approach to Hair Restoration Plastic and Reconstructive Surgery · 2021
    4. Use of Human Intra-Tissue Stem/Progenitor Cells and Induced Pluripotent Stem Cells for Hair Follicle Regeneration PubMed · 2019
    5. Platelet-Derived Growth Factor Signaling Modulates Adult Hair Follicle Dermal Stem Cell Maintenance and Self-Renewal npj Regenerative Medicine · 2017