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GlossaryXenografts

transplantation of tissues or organs between different species

Xenografts, also known as xenotransplants, refer to the transplantation of cells, tissues, or organs from one species to another. For example, using pig skin grafts to treat human burn victims. This technique is often explored in medical research to address the shortage of human donors for organ transplants and to study disease mechanisms.

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research In Vitro Cultivation of Dermal-Epidermal Composites in a Single Medium Supports Human Hair Follicle Neogenesis in Xenografts

July 2024 in “Journal of Investigative Dermatology”

A single medium, PRIME AIRLIFT, supports better human hair follicle formation in grafts.

research Sympathetic Reinnervation of Intact and Upper Follicle Xenografts into BALB/c-nu/nu Mice

November 2023 in “Life”

Transplanted rat hair follicles grew hair and had increased but not fully restored nerve connections in mice.

research Steroidogenesis Inhibitors Alter But Do Not Eliminate Androgen Synthesis Mechanisms During Progression to Castration-Resistance in LNCaP Prostate Xenografts

57 citations, April 2009 in “The Journal of Steroid Biochemistry and Molecular Biology”

Steroidogenesis inhibitors change but don't stop androgen production in prostate cancer.

research Interaction Between Stem Cell Factor and Endothelin-1: Effects on Melanogenesis in Human Skin Xenografts

27 citations, August 2006 in “Laboratory Investigation”

SCF and ET-1 together significantly increase skin pigmentation and melanin production.

research Sebaceous Gland Regeneration in Human Skin Xenografts

9 citations, May 2010 in “Journal of Investigative Dermatology”

Human sebaceous glands can grow back in skin grafts on mice and work like normal human glands.

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community This is the best time in human history to be fighting hair loss

in Treatment 193 upvotes 2 years ago

This conversation discusses the advancements in treatments for hair loss, including finasteride, dutasteride, minoxidil and new promising treatments such as pyrilutamide and verteporfin. Other treatments discussed were taking minoxidil orally, tretinoin to turn non-responders into responders and microneedling to further boost growth.

community Expectations control for SCUBE3

in Research/Science 21 upvotes 9 months ago

SCUBE3, a protein linked to hair growth in moles, was discovered over 25 years ago and is being developed by Amplifica for potential hair loss treatment. Concerns exist about SCUBE3's association with cancer, as it is a protein that promotes cell growth, which could potentially trigger cancer development if used for hair growth therapy.