TLDR iPSC-derived stem cells on a special membrane can help repair full-thickness skin defects.
The study demonstrated that induced pluripotent stem cell (iPSC)-derived epithelial stem cells (EpSCs) seeded on a human acellular amniotic membrane (hAAM) could effectively repair full-thickness skin defects in nude mice. iPSCs were reprogrammed from urinary cells and differentiated into EpSCs, which adhered to hAAM and promoted skin regeneration. The composite of hAAM and iPSC-derived EpSCs significantly accelerated wound healing and facilitated the formation of new hair follicles, indicating its potential as a viable skin substitute. However, challenges such as increased apoptosis of induced cells and maintaining the moisture of amniotic membranes were noted, suggesting the need for further research to improve cell proliferation stability and scaffold performance.
45 citations,
October 2014 in “Stem cell research & therapy” Modified rat stem cells on a special scaffold improved blood vessel formation and wound healing in skin substitutes.
68 citations,
August 2014 in “Stem Cells Translational Medicine” Dermal papilla cells help wounds heal better and can potentially grow new hair.
99 citations,
January 2014 in “Nature communications” Scientists created stem cells that can grow hair and skin.
101 citations,
December 2010 in “The journal of investigative dermatology/Journal of investigative dermatology” Scientists turned mouse stem cells into skin cells that can grow into skin layers and structures.
829 citations,
May 2007 in “Nature” Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.
1 citations,
June 2023 in “Journal of Cellular and Molecular Medicine” The new method using gene-modified stem cells and a 3D printed scaffold improved skin repair in mice.
99 citations,
January 2014 in “Nature communications” Scientists created stem cells that can grow hair and skin.
May 2023 in “Frontiers in Cell and Developmental Biology” The document concludes that using stem cells to regenerate hair follicles could be a promising treatment for hair loss, but there are still challenges to overcome before it can be used clinically.
232 citations,
October 2015 in “International journal of molecular sciences” Stem cells are crucial for skin repair and new treatments for chronic wounds.
4 citations,
January 2021 in “Cell transplantation” Scientists found the best time to transplant human stem cells for hair growth is between days 16-18 when they have the right markers and growth potential.
