Application and Progress of Induced Pluripotent Stem Cells in Chronic Wound Healing: A Narrative Review

    February 2026 in “ BMC Plastic and Reconstructive Surgery ”
    Yuyao Lin, YuJie Yan, Chao Qu … Maoguo Shu
    Studysummary This review suggests that induced pluripotent stem cells (iPSCs) hold promise for treating chronic wounds, but further work is needed to address safety, efficacy, and translation from preclinical models to real-world applications.
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    Research cited in this study 6

    1. Skin Organoids: A New Human Model for Developmental and Translational Research Experimental Dermatology · 2021
    2. Hair-Bearing Human Skin Generated Entirely From Pluripotent Stem Cells Nature · 2020
    3. Feasibility of Repairing Full-Thickness Skin Defects by iPSC-Derived Epithelial Stem Cells Seeded on a Human Acellular Amniotic Membrane Stem cell research & therapy · 2019
    4. Next Generation Human Skin Constructs as Advanced Tools for Drug Development Experimental Biology and Medicine · 2017
    5. Generation of Folliculogenic Human Epithelial Stem Cells from Induced Pluripotent Stem Cells Nature communications · 2014
    6. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007