Electrical Stimulation to Human Dermal Papilla Cells for Hair Regenerative Medicine

    Lu Yan, Tatsuto Kageyama, Binbin Zhang Molino, Seiya Yamashita, Paul J. Molino, Gordon G. Wallace, Junji Fukuda
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    TLDR Electric stimulation can increase hair growth by activating certain genes in skin cells.
    The study "Electrical stimulation to human dermal papilla cells for hair regenerative medicine" investigated the effects of electrical stimulation (ES) on human dermal papilla cells (hDPCs), which are crucial for hair formation and growth. The researchers found that ES using a polypyrrole-modified electrode increased trichogenic gene expression in hDPCs. When these activated cells were transplanted into mice, they produced twice the number of hairs compared to those without ES. The study also revealed that the mechanisms behind this electrical activation are associated with voltage-gated ion channels. Furthermore, the ES method was found to be adaptable for hDPCs from a patient with androgenic alopecia, suggesting potential benefits for hair regenerative medicine.
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