Impact of Adipose-Derived Stem Cells on Engineering Hair Follicle Germ-Like Tissue Grafts for Hair Regenerative Medicine

    Rikuma Nakajima, Yoshiki Tate, Lu Yan, Tatsuto Kageyama, Junji Fukuda
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    TLDR Adding human fat-derived stem cells to hair follicle grafts greatly increases hair growth.
    The study explored the role of human adipose-derived stem cells (hASCs) in creating hair follicle germ (HFG)-like tissues and their effect on hair regeneration. Researchers combined hASCs with human dermal papilla cells (hDPCs) and murine embryonic epithelial cells to form HFG-like aggregates. These aggregates self-organized into a structure conducive to hair growth, with hASCs enhancing gene expression related to hair development. When transplanted into nude mice, the HFG-like tissues containing hASCs produced significantly more hair shafts than those without hASCs, indicating a 14-fold increase in hair generation. Histological analysis confirmed the formation of hair follicles with typical features. The findings suggest that hASCs could be a promising addition to tissue grafts for hair regenerative medicine, although further research is needed, particularly with human cells from alopecia patients.
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