Functional Complexity of Hair Follicle Stem Cell Niche and Therapeutic Targeting of Niche Dysfunction for Hair Regeneration

    March 2020 in “ Journal of Biomedical Science
    Chih-Lung Chen, Wen-Yen Huang, Eddy Hsi Chun Wang, Kang-Yu Tai, Sung-Jan Lin
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    TLDR Understanding how hair follicle stem cells work can help find new ways to prevent hair loss and promote hair growth.
    In 2020, Chen et al. investigated the hair follicle stem cell (HFSC) niche's complexity and its role in hair regeneration. The study divided the cells in the HFSC niche into three functional groups: signaling, sensing, and message-relaying. Dysfunction in these cells can lead to hair loss conditions like androgenetic alopecia and alopecia areata. The document also discussed the role of immune cells in modulating HFSCs activity and the use of 5-alpha-reductase inhibitors and minoxidil as treatments for androgenetic alopecia. The study emphasized the role of adipose tissue and sympathetic nerves in hair growth. The document concluded that understanding how HFSCs are regulated could uncover new therapeutic targets to prevent hair loss and promote hair regeneration.
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