High-Throughput T Cell Receptor Sequencing Identifies Clonally Expanded CD8+ T Cell Populations in Alopecia Areata

    October 2018 in “ JCI insight ”
    Annemieke de Jong, Ali Jabbari, Zhijun Dai … Angela M. Christiano
    Studysummary In this study, the researchers found that treatment with the JAK inhibitor tofacitinib in alopecia areata patients may reduce clonal CD8+ T cell expansions but does not eliminate them entirely, which could contribute to disease relapse.
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    Research cited in this study 12

    1. An Open-Label Pilot Study to Evaluate the Efficacy of Tofacitinib in Moderate to Severe Patch-Type Alopecia Areata, Totalis, and Universalis Journal of Investigative Dermatology · 2018
    2. Treatment of Alopecia Areata With Tofacitinib JAMA Dermatology · 2017
    3. Tofacitinib for the Treatment of Severe Alopecia Areata and Variants: A Study of 90 Patients Journal of The American Academy of Dermatology · 2016
    4. Safety and Efficacy of the JAK Inhibitor Tofacitinib Citrate in Patients with Alopecia Areata JCI insight · 2016
    5. Treatment of an Alopecia Areata Patient with Tofacitinib Results in Regrowth of Hair and Changes in Serum and Skin Biomarkers Experimental Dermatology · 2016
    6. Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition Nature medicine · 2014
    7. Alopecia Areata: An Autoimmune Disease Causing Hair Loss The New England Journal of Medicine · 2012
    8. Trichohyalin Is a Potential Major Autoantigen in Human Alopecia Areata Journal of Proteome Research · 2010
    9. Genome-Wide Association Study in Alopecia Areata Implicates Both Innate and Adaptive Immunity Nature · 2010
    10. Melanocytes: A Possible Autoimmune Target in Alopecia Areata Journal of the American Academy of Dermatology · 2009
    11. Characterization of Hair Follicle Antigens Targeted by the Anti-Hair Follicle Immune Response Journal of Investigative Dermatology Symposium Proceedings · 2003
    12. Experimental Induction of Alopecia Areata-Like Hair Loss in C3H/HeJ Mice Using Full-Thickness Skin Grafts ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1998

    Related research 1

    1. The Role of Lymphocytes in the Development and Treatment of Alopecia Areata Expert Review of Clinical Immunology · 2015