Melanocytes: A Possible Autoimmune Target in Alopecia Areata

    Stephanie Trautman, Michele M. Thompson, Janet L. Roberts, Curtis T. Thompson
    TLDR Melanocytes might be targeted by the immune system in people with alopecia areata, but more research is needed.
    The study investigated the role of melanocytes as potential autoimmune targets in alopecia areata (AA). Using immunoperoxidase stains on scalp samples from 18 AA patients, researchers found a significant reduction in melanocyte density compared to 5 control subjects. Specifically, 72% of AA patients showed only trace to 1+ staining for melanocytes, while all control samples exhibited 3+ staining. This reduction was observed across all hair growth phases. The findings suggested a decreased number of follicular melanocytes in AA, but it remained unclear whether this was due to autoimmune attack or rapid hair cycling. Further research was needed to distinguish between these possibilities.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community Great news recently for people with hairloss!

      in Research/Science  113 upvotes 2 weeks ago
      A potential treatment for alopecia involving a protein that calms hair follicles has shown promise in rats, but skepticism remains about its applicability to humans. Many users express doubt about the timeline for effective hair loss treatments, comparing it to past unfulfilled promises.

      community Alopecia Areata Question

      in Treatment  2 upvotes 4 years ago
      A user with alopecia totalis, borderline universalis, seeks advice on getting into a Xeljanz trial or appealing insurance for coverage. They experienced significant hair regrowth but are now seeing hair loss again and want to try Xeljanz.

      community mbp alopecia areata or vitamin deficiency

      in Chat 10 months ago
      A 19-year-old male has been using topical finasteride and minoxidil for 8 months with no progress and is considering seeking a second opinion due to potential misdiagnosis. The discussion revolves around whether the hair loss is due to male pattern baldness, alopecia areata, or a vitamin deficiency.

      community Olumiant alternative for Alopecia Areata?

      in Treatment  1 upvotes 2 years ago
      A user with alopecia areata is considering treatment options like injections or Olumiant but is concerned about cost and whether delaying treatment will lead to permanent hair loss. They are seeking alternative treatments that are more affordable for a college student.

    Related Research

    4 / 4 results