The Efficacy of Adipose-Derived Stem Cells in Burn Injuries: A Systematic Review

January 2024 in “ Cellular & Molecular Biology Letters ”

Michael Kohlhauser, Alexandru Tuca, Lars‐Peter Kamolz

adipose-derived stem cells ADSCs wound healing immunoregulation neovascularization granulation tissue formation re-epithelialization remodeling stem cells

TLDR Adipose-derived stem cells help heal burns but need more research.

This systematic review evaluates the efficacy of adipose-derived stem cells (ADSCs) in treating burn injuries across 21 animal studies involving 517 animals, primarily rodents. The review found that ADSCs significantly enhance wound healing by improving immunoregulation, neovascularization, granulation tissue formation, re-epithelialization, and remodeling. Despite these promising results, the application of ADSCs in burn care remains in the early experimental stages, with significant methodological weaknesses identified, such as unclear risks of selection, performance, and detection biases. Further research with more rigorous study designs is needed to optimize the therapeutic potential of ADSCs in clinical settings.

View this study on cmbl.biomedcentral.com →

Discuss this study in the Community →

Research cited in this study

18 / 18 results

research Wound-Induced Hair Neogenesis Model

5 citations, September 2022 in “Journal of Investigative Dermatology”

Careful selection of mice by genetics and age, and controlled housing conditions improve the reliability of hair regrowth in wound healing tests.

research Symmetry Breaking of Tissue Mechanics in Wound-Induced Hair Follicle Regeneration of Laboratory and Spiny Mice

22 citations, May 2021 in “Nature Communications”

Tissue stiffness affects hair follicle regeneration, and Twist1 is a key regulator.

research Bacteria Induce Skin Regeneration via IL-1β Signaling

53 citations, April 2021 in “Cell Host & Microbe”

Skin bacteria, specifically Staphylococcus aureus, help in wound healing and hair growth by using IL-1β signaling. Using antibiotics on skin wounds can slow down this natural healing process.

research Immune Modulation of Hair Follicle Regeneration

29 citations, May 2020 in “npj Regenerative Medicine”

Immune cells help regulate hair growth, and better understanding this can improve hair loss treatments.

research Adipose Stem Cells Isolated From Diabetic Mice Improve Cutaneous Wound Healing In Streptozotocin-Induced Diabetic Mice

29 citations, March 2020 in “Stem Cell Research & Therapy”

Fat stem cells from diabetic mice can help heal skin wounds in other diabetic mice.

research Toward Understanding Scarless Skin Wound Healing and Pathological Scarring

113 citations, June 2019 in “F1000Research”

Scarless healing is complex and influenced by genetics and environment, while better understanding could improve scar treatment.

research Wound Healing: A Cellular Perspective

1160 citations, November 2018 in “Physiological Reviews”

The document concludes that better targeted treatments are needed for wound healing, and single-cell technologies may improve cell-based therapies.

research Hedgehog Stimulates Hair Follicle Neogenesis by Creating Inductive Dermis During Murine Skin Wound Healing

145 citations, November 2018 in “Nature Communications”

The Sonic hedgehog pathway is crucial for new hair growth during mouse skin healing.

research Cutaneous Scarring: Basic Science, Current Treatments, and Future Directions

178 citations, August 2016 in “Advances in wound care”

New effective scar treatments are urgently needed due to the current options' limited success.

research dsRNA Released by Tissue Damage Activates TLR3 to Drive Skin Regeneration

128 citations, August 2015 in “Cell Stem Cell”

Damage to skin releases dsRNA, which activates TLR3 and helps in skin and hair follicle regeneration.

research Hair Transplantation in Burn Scar Alopecia

8 citations, January 2015 in “Scars, burns & healing”

Hair transplantation effectively treats burn scar alopecia, improving self-esteem and confidence.

research Concise Review: Tissue-Engineered Skin and Nerve Regeneration in Burn Treatment

84 citations, June 2013 in “Stem Cells Translational Medicine”

New methods for skin and nerve regeneration can improve healing and feeling after burns.

research Fgf9 From Dermal γδ T Cells Induces Hair Follicle Neogenesis After Wounding

237 citations, June 2013 in “Nature Medicine”

A protein from certain immune cells is key for new hair growth after skin injury in mice.

research Prostaglandin D2 Inhibits Wound-Induced Hair Follicle Neogenesis Through the Receptor Gpr44

68 citations, November 2012 in “Journal of Investigative Dermatology”

Prostaglandin D2 blocks new hair growth after skin injury through the Gpr44 receptor.

research Skin Shedding and Tissue Regeneration in African Spiny Mice (Acomys)

418 citations, September 2012 in “Nature”

African spiny mice can regenerate skin, hair, and cartilage, but not muscle, and their unique abilities could be useful for regenerative medicine.

research Hair Follicle Regeneration in Skin Grafts: Current Concepts and Future Perspectives

39 citations, September 2011 in “Tissue Engineering Part B-reviews”

Hair follicle regeneration in skin grafts may be possible using stem cells and tissue engineering.

research Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling

499 citations, September 2011 in “Cell”

Fat-related cells are important for initiating hair growth.

research Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding

829 citations, May 2007 in “Nature”

Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.

Related Community Posts Join

6 / 27 results

community UPDATE: The theory that explains everything. Please help me make this big!

in Research/Science 441 upvotes 3 years ago

Hair loss theory involves 3alpha-hydroxysteroid reductase (3AHD) converting DHT to androstenol. Discussion explores potential treatments and encourages more research.

community STEM CELL TREATMENT FOR HAIR LOSS at home

in Treatment 6 upvotes 3 years ago

User considers trying AAPE for hair restoration, costing $700 for 6 months. Others discuss its potential effectiveness and mention a study with promising results.

community Anyone Try Microneedling with Exosomes/AAPE?

in Microneedling 2 upvotes 2 years ago

User asks where to purchase exosomes/AAPE for microneedling hair loss treatment. Links to research on hair regeneration therapy, stem cell therapy, exosome therapy, and dermal exosomes provided.

community Can we have a thread that summarizes all treatments options in addition to the big 3 which we have some evidence for, their mechanism of action and whether they can be combined with the big 3(other than dermarolling)?

in Treatment 52 upvotes 6 years ago

The conversation discusses hair loss treatments beyond the commonly known three, focusing on separating effective treatments from myths. Dutasteride and low-dose oral Minoxidil are mentioned as having clinical evidence for increasing hair counts, but with potential side effects.

community My opinions on hair treatment right now and in future

in Treatment 22 upvotes 5 years ago

Finasteride, minoxidil, dermarolling, and topical antiandrogens are effective for hair regrowth. Future treatments may include CB0301 and hair cloning.

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 4 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

Similar Research

5 / 1000+ results

research Cellular Therapeutics and Immunotherapies in Wound Healing – On the Pulse of Time?

April 2024 in “Military Medical Research/Military medical research”

Cellular and immunotherapies show promise for healing chronic wounds but need more research.

research The Therapeutic Role of ADSC-EVs in Skin Regeneration

7 citations, June 2022 in “Frontiers in Medicine”

ADSC-derived extracellular vesicles show promise for skin and hair regeneration and wound healing.

research Going Below and Beyond the Surface: Microneedle Structure, Materials, Drugs, Fabrication, and Applications for Wound Healing and Tissue Regeneration

61 citations, April 2023 in “Bioactive Materials”

Microneedles are effective for painless drug delivery and promoting wound healing and tissue regeneration.

research Application of Mesenchymal Stem Cells for Anti-Senescence and Clinical Challenges

1 citations, September 2023 in “Stem cell research & therapy”

Mesenchymal stem cells could help treat aging-related diseases better than current methods.

research Orchestration of Mesenchymal Stem/Stromal Cells and Inflammation During Wound Healing

July 2023 in “Stem Cells Translational Medicine”

Mesenchymal Stem/Stromal Cells (MSCs) help in wound healing and tissue regeneration, but can also contribute to tumor growth. They show promise in treating chronic wounds and certain burns, but their full healing mechanisms and potential challenges need further exploration.