Therapeutic Potential of Adipose-Derived Stem Cells and Their Secretome in Reversible Alopecias: A Systematic Review

    September 2023 in “ International Journal of Trichology
    Alexis Ortega-Cuartiella
    TLDR Adipose-derived stem cells may help with hair loss, but more research is needed.
    Androgenic alopecia (AGA) and alopecia areata (AA) significantly impact quality of life, and current treatments are often ineffective. Adipose-derived stem cells (ADSCs) show promise for hair follicle regeneration, with ADSCs isolated as stromal vascular fraction (SVF) or nanofat, and ADSC-conditioned medium (CM) as a cost-effective alternative. A systematic review of 11 studies (1 RCT, 10 case-control or case series) on humans with AGA or AA using SVF, nanofat, or ADSC-CM found positive but inconsistent results, leading to a Level D NICE recommendation. Further randomized controlled trials with standardized methods are needed to confirm these findings.
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