Therapeutic Potential of Adipose-Derived Stem Cells and Their Secretome in Reversible Alopecias: A Systematic Review

    September 2023 in “ International Journal of Trichology
    Alexis Ortega-Cuartiella
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    TLDR Adipose-derived stem cells may help with hair loss, but more research is needed.
    This systematic review evaluates the therapeutic potential of adipose-derived stem cells (ADSCs) and their secretome in treating androgenic alopecia (AGA) and alopecia areata (AA). Despite methodological flaws such as lack of randomization, small sample sizes, and confounding factors, all 11 studies reviewed reported positive outcomes, including increased hair growth and patient satisfaction. Study 8, with 60 subjects, provided the most reliable data, showing improvements in hair density and thickness. However, the overall low level of evidence calls for larger, well-designed randomized controlled trials to confirm the efficacy of ADSC-based therapies for hair loss and to establish standardized procedures for their use.
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