Repeated Microneedle Stimulation Induces Enhanced Hair Growth in a Murine Model

In the 2016 study, researchers demonstrated that microneedle stimulation can enhance hair growth in mice by activating hair growth-related genes and pathways, specifically the Wnt/β-catenin signaling pathway and increasing VEGF expression. The optimal conditions for hair growth were found to be with microneedles of 0.25 mm and 0.5 mm lengths used for 10 cycles. The findings suggest that microneedle stimulation could be a potential non-pharmacological treatment for alopecia. However, the study was limited to a murine model and did not address the variability in human application. Despite these limitations, the results indicate that microneedle stimulation alone can induce hair growth, providing a basis for future research into treatments for hair loss.