Clinical Utility and Validity of Minoxidil Response Testing in Androgenetic Alopecia

August 2014 in “ Dermatologic Therapy ”

Andy Goren, Jerry Shapiro, Janet L. Roberts, John D. McCoy, Nisha Desai, Z Zarrab, Aldona Pietrzak, Torello Lotti

minoxidil androgenetic alopecia minoxidil response testing Rogaine AGA

Studysummary This study confirmed that a sulfotransferase enzyme test can effectively rule out 95.9% of nonresponders to 5% topical minoxidil for treating androgenetic alopecia.

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Sulfotransferase Activity in Plucked Hair Follicles Predicts Response to Topical Minoxidil in the Treatment of Female Androgenetic Alopecia

research Sulfotransferase Activity in Plucked Hair Follicles Predicts Response to Topical Minoxidil in the Treatment of Female Androgenetic Alopecia

20 citations , April 2014 in “Dermatologic Therapy”

This study reported that sulfotransferase activity in plucked hair follicles can predict treatment response to 5% topical minoxidil in women with androgenetic alopecia with high sensitivity and specificity.

research Novel Enzymatic Assay Predicts Minoxidil Response in the Treatment of Androgenetic Alopecia

27 citations , November 2013 in “Dermatologic Therapy”

This study suggests that a hair follicle enzyme assay may predict response to minoxidil treatment for androgenetic alopecia with high sensitivity and specificity in a preliminary analysis.

A Multicenter, Randomized, Placebo-Controlled, Double-Blind Clinical Trial of a Novel Formulation of 5% Minoxidil Topical Foam Versus Placebo in the Treatment of Androgenetic Alopecia in Men

research A Multicenter, Randomized, Placebo-Controlled, Double-Blind Clinical Trial of a Novel Formulation of 5% Minoxidil Topical Foam Versus Placebo in the Treatment of Androgenetic Alopecia in Men

142 citations , August 2007 in “Journal of The American Academy of Dermatology”

This study found that a new 5% minoxidil foam formulation significantly increased hair counts and improved hair loss condition in men with androgenetic alopecia over 16 weeks compared to placebo.

A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men

research A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men

269 citations , August 2002 in “Journal of The American Academy of Dermatology”

This study found that 5% topical minoxidil significantly increased hair regrowth and improved psychosocial perceptions of hair loss in men with androgenetic alopecia compared to 2% topical minoxidil and placebo over 48 weeks.

research Sulfation of Minoxidil by Multiple Human Cytosolic Sulfotransferases

59 citations , February 1998 in “Chemico-Biological Interactions”

This study found that at least four different human sulfotransferase activities contribute to the sulfation of minoxidil, complicating predictions of individual responses based on ST levels.

research Minoxidil Sulfation in the Hair Follicle

32 citations , January 1994 in “Skin Pharmacology and Physiology”

In this study, scalp skin from stumptailed macaques demonstrated minoxidil sulfotransferase activity primarily in hair follicles, which may explain minoxidil's hair growth stimulation in this model.

research Minoxidil Sulfate Is the Active Metabolite That Stimulates Hair Follicles

166 citations , November 1990 in “Journal of Investigative Dermatology”

Minoxidil sulfate stimulates hair growth.