Sulfotransferase Activity in Plucked Hair Follicles Predicts Response to Topical Minoxidil in the Treatment of Female Androgenetic Alopecia

April 2014 in “ Dermatologic Therapy ”

Janet L. Roberts, Nisha Desai, John D. McCoy, Andy Goren

sulfotransferase activity plucked hair follicles topical minoxidil female androgenetic alopecia biomarker Rogaine

Studysummary This study reported that sulfotransferase activity in plucked hair follicles can predict treatment response to 5% topical minoxidil in women with androgenetic alopecia with high sensitivity and specificity.

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Research cited in this study

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research Interventions for Female Pattern Hair Loss

35 citations , May 2012 in “Cochrane Database of Systematic Reviews”

This review found evidence supporting the effectiveness and safety of topical minoxidil for treating female pattern hair loss, though many included studies were at high risk of bias.

A Multicenter, Randomized, Placebo-Controlled, Double-Blind Clinical Trial of a Novel Formulation of 5% Minoxidil Topical Foam Versus Placebo in the Treatment of Androgenetic Alopecia in Men

research A Multicenter, Randomized, Placebo-Controlled, Double-Blind Clinical Trial of a Novel Formulation of 5% Minoxidil Topical Foam Versus Placebo in the Treatment of Androgenetic Alopecia in Men

142 citations , August 2007 in “Journal of The American Academy of Dermatology”

This study found that a new 5% minoxidil foam formulation significantly increased hair counts and improved hair loss condition in men with androgenetic alopecia over 16 weeks compared to placebo.

research A Randomized, Placebo-Controlled Trial of 5% and 2% Topical Minoxidil Solutions in the Treatment of Female Pattern Hair Loss

219 citations , March 2004 in “Journal of The American Academy of Dermatology”

In this 48-week trial, 5% topical minoxidil was more effective than both 2% minoxidil and placebo in promoting hair growth in women with female pattern hair loss, with notable improvements in nonvellus hair count and hair growth assessments.

research Sulfation of Minoxidil by Multiple Human Cytosolic Sulfotransferases

59 citations , February 1998 in “Chemico-Biological Interactions”

This study found that at least four different human sulfotransferase activities contribute to the sulfation of minoxidil, complicating predictions of individual responses based on ST levels.

research Diffuse Hypertrichosis During Treatment with 5% Topical Minoxidil

44 citations , January 1997 in “British Journal of Dermatology”

In this study, five women with androgenetic alopecia experienced severe facial and limb hypertrichosis after using 5% topical minoxidil, which resolved after discontinuing the treatment.

research Androgenetic Alopecia in the Female

82 citations , March 1994 in “Archives of Dermatology”

This study found that a 2% topical minoxidil solution significantly increased hair regrowth compared to placebo in women with androgenetic alopecia over 32 weeks.

research Minoxidil Sulfation in the Hair Follicle

32 citations , January 1994 in “Skin Pharmacology and Physiology”

In this study, scalp skin from stumptailed macaques demonstrated minoxidil sulfotransferase activity primarily in hair follicles, which may explain minoxidil's hair growth stimulation in this model.

research Use of Topical Minoxidil Therapy for Androgenetic Alopecia in Women

58 citations , October 1993 in “International Journal of Dermatology”

This study found that 2% topical minoxidil solution was significantly more effective than placebo in promoting new hair growth in women with androgenetic alopecia.

research Minoxidil Sulfate Is the Active Metabolite That Stimulates Hair Follicles

166 citations , November 1990 in “Journal of Investigative Dermatology”

Minoxidil sulfate stimulates hair growth.