Sulfotransferase Activity in Plucked Hair Follicles Predicts Response to Topical Minoxidil in the Treatment of Female Androgenetic Alopecia

April 2014 in “ Dermatologic Therapy ”

Janet L. Roberts, Nisha Desai, John D. McCoy, Andy Goren

sulfotransferase activity plucked hair follicles topical minoxidil female androgenetic alopecia biomarker Rogaine

TLDR Sulfotransferase in hair follicles helps predict how well minoxidil works for female hair loss.

Measuring sulfotransferase activity in plucked hair follicles can predict the response to topical minoxidil treatment in female androgenetic alopecia with 93% sensitivity and 83% specificity. This suggests that sulfotransferase activity can be used as a biomarker to predict treatment response in female androgenetic alopecia.

View this study on onlinelibrary.wiley.com →

Discuss this study in the Community →

Research cited in this study

9 / 9 results

research Interventions for Female Pattern Hair Loss

35 citations, May 2012 in “Cochrane Database of Systematic Reviews”

Minoxidil effectively treats female pattern hair loss.

A Multicenter, Randomized, Placebo-Controlled, Double-Blind Clinical Trial of a Novel Formulation of 5% Minoxidil Topical Foam Versus Placebo in the Treatment of Androgenetic Alopecia in Men

research A Multicenter, Randomized, Placebo-Controlled, Double-Blind Clinical Trial of a Novel Formulation of 5% Minoxidil Topical Foam Versus Placebo in the Treatment of Androgenetic Alopecia in Men

142 citations, August 2007 in “Journal of The American Academy of Dermatology”

New 5% minoxidil foam effectively promotes hair growth and is safe for use.

research A Randomized, Placebo-Controlled Trial of 5% and 2% Topical Minoxidil Solutions in the Treatment of Female Pattern Hair Loss

219 citations, March 2004 in “Journal of The American Academy of Dermatology”

5% and 2% minoxidil solutions effectively promote hair growth and reduce hair loss, with 5% being slightly more effective but having more side effects.

research Sulfation of Minoxidil by Multiple Human Cytosolic Sulfotransferases

59 citations, February 1998 in “Chemico-Biological Interactions”

Minoxidil breakdown varies by enzymes, affecting hair loss treatment effectiveness.

research Diffuse Hypertrichosis During Treatment with 5% Topical Minoxidil

44 citations, January 1997 in “British Journal of Dermatology”

research Androgenetic Alopecia in the Female

82 citations, March 1994 in “Archives of Dermatology”

2% topical minoxidil effectively treats female hair loss with minimal side effects.

research Minoxidil Sulfation in the Hair Follicle

32 citations, January 1994 in “Skin Pharmacology and Physiology”

Minoxidil helps hair growth by activating enzymes in hair follicles.

research Use of Topical Minoxidil Therapy for Androgenetic Alopecia in Women

58 citations, October 1993 in “International Journal of Dermatology”

Minoxidil helps hair growth and reduces shedding in women.

research Minoxidil Sulfate Is the Active Metabolite That Stimulates Hair Follicles

166 citations, November 1990 in “Journal of Investigative Dermatology”

Minoxidil sulfate stimulates hair growth.

Similar Research

6 / 286 results

research Doppler Laser Imaging Predicts Response to Topical Minoxidil in the Treatment of Female Pattern Hair Loss

7 citations, April 2016 in “PubMed”

Laser Doppler imaging can predict how well minoxidil will work for female hair loss.

Efficacy, Tolerability, and Superiority of Propylene Glycol-Free, North American Witch-Hazel-Based Solution of 5% Minoxidil Sulfate for the Treatment of Female Androgenetic Alopecia

research Efficacy, Tolerability, and Superiority of Propylene Glycol-Free, North American Witch-Hazel-Based Solution of 5% Minoxidil Sulfate for the Treatment of Female Androgenetic Alopecia

May 2023 in “International Journal of Trichology”

A witch-hazel-based 5% minoxidil solution is effective and safe for women with hair loss who didn't respond to regular minoxidil, especially if they're sensitive to propylene glycol.

research Oral Minoxidil in Trichology: A Review

January 2022 in “Indian journal of drugs in dermatology”

Oral minoxidil helps with hair growth but needs more research to fully understand its effectiveness and safety.

research Clinical Utility and Validity of Minoxidil Response Testing in Androgenetic Alopecia

43 citations, August 2014 in “Dermatologic Therapy”

Minoxidil response testing helps treat hair loss effectively and safely.

research Female Pattern Hair Loss: Therapeutic Update

March 2023 in “Anais Brasileiros De Dermatologia”

Topical minoxidil is the best-supported treatment for female hair loss, but personalized plans are needed.

research Treatment of Androgenetic Alopecia: Current Guidance and Unmet Needs

May 2023 in “Clinical, Cosmetic and Investigational Dermatology”

More personalized and effective treatments for androgenetic alopecia are needed.