Efficacy, Tolerability, and Superiority of Propylene Glycol-Free, North American Witch-Hazel-Based Solution of 5% Minoxidil Sulfate for the Treatment of Female Androgenetic Alopecia

    Ralph M. Trüeb
    Studysummary In this study, 70% of female androgenetic alopecia patients who did not respond to standard minoxidil experienced clinical improvement after switching to a propylene glycol-free, witch hazel-based 5% minoxidil sulfate solution, with the treatment also being well-tolerated.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on journals.lww.com →
    Discuss this study in the Community →

    Research cited in this study 14

    1. Use of Minoxidil Sulfate Versus Minoxidil Base in Androgenetic Alopecia Treatment: Friend or Foe? Skin appendage disorders · 2018
    2. The Role of Oxidative Damage in Poor Scalp Health: Ramifications to Causality and Associated Hair Growth International Journal of Cosmetic Science · 2015
    3. Is Seborrhoeic Dermatitis Associated with Diffuse, Low-Grade Folliculitis and Progressive Cicatricial Alopecia? Australasian Journal of Dermatology · 2015
    4. Clinical Utility and Validity of Minoxidil Response Testing in Androgenetic Alopecia Dermatologic Therapy · 2014
    5. Sulfotransferase Activity in Plucked Hair Follicles Predicts Response to Topical Minoxidil in the Treatment of Female Androgenetic Alopecia Dermatologic Therapy · 2014
    6. New Ethanol and Propylene Glycol Free Gel Formulations Containing a Minoxidil-Methyl-Beta-Cyclodextrin Complex as Promising Tools for Alopecia Treatment Drug Development and Industrial Pharmacy · 2014
    7. North American Virginian Witch Hazel (Hamamelis Virginiana): Scalp Care and Protection for Sensitive Scalp, Red Scalp, and Scalp Burn-Out International Journal of Trichology · 2014
    8. Novel Enzymatic Assay Predicts Minoxidil Response in the Treatment of Androgenetic Alopecia Dermatologic Therapy · 2013
    9. A Randomized, Single-Blind Trial of 5% Minoxidil Foam Once Daily Versus 2% Minoxidil Solution Twice Daily in the Treatment of Androgenetic Alopecia in Women Journal of The American Academy of Dermatology · 2011
    10. Premature Senescence of Balding Dermal Papilla Cells In Vitro Is Associated With p16INK4a Expression Journal of Investigative Dermatology · 2007
    11. Is Androgenetic Alopecia a Photoaggravated Dermatosis? Dermatology · 2003
    12. Minoxidil-Induced Hair Growth Is Mediated by Adenosine in Cultured Dermal Papilla Cells: Possible Involvement of Sulfonylurea Receptor 2B as a Target of Minoxidil Journal of Investigative Dermatology · 2001
    13. Minoxidil Sulfation in the Hair Follicle Skin Pharmacology and Physiology · 1994
    14. Minoxidil Sulfate Is the Active Metabolite That Stimulates Hair Follicles Journal of Investigative Dermatology · 1990

    Related research 4

    1. The Cost Effectiveness of Topical Minoxidil Therapy in the Management of Baldness The FASEB Journal · 2011
    2. Topical Minoxidil Does Little for Baldness Drug and Therapeutics Bulletin · 1989
    3. Topical Minoxidil (3%) in Extensive Alopecia Areata, Including Long-Term Efficacy Journal of The American Academy of Dermatology · 1987
    4. Dose-Response Study of Topical Minoxidil in Male Pattern Baldness Journal of The American Academy of Dermatology · 1986