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Glossary propylene glycol

synthetic liquid that enhances skin absorption of active ingredients

Propylene glycol is a synthetic liquid substance that absorbs water and is commonly used as a solvent in pharmaceuticals, including topical treatments for hair and skin conditions. It helps active ingredients penetrate the skin more effectively and is generally considered safe for use, though some individuals may experience skin irritation.

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Efficacy, Tolerability, and Superiority of Propylene Glycol-Free, North American Witch-Hazel-Based Solution of 5% Minoxidil Sulfate for the Treatment of Female Androgenetic Alopecia

research Efficacy, Tolerability, and Superiority of Propylene Glycol-Free, North American Witch-Hazel (Hamamelis virginiana)-Based Solution of 5% Minoxidil Sulfate for the Treatment of Female Androgenetic Alopecia

May 2023 in “International Journal of Trichology”

In this study, 70% of female androgenetic alopecia patients who did not respond to standard minoxidil experienced clinical improvement after switching to a propylene glycol-free, witch hazel-based 5% minoxidil sulfate solution, with the treatment also being well-tolerated.

New Ethanol and Propylene Glycol Free Gel Formulations Containing a Minoxidil-Methyl-Beta-Cyclodextrin Complex as Promising Tools for Alopecia Treatment

research New ethanol and propylene glycol free gel formulations containing a minoxidil-methyl-β-cyclodextrin complex as promising tools for alopecia treatment

18 citations , March 2014 in “Drug Development and Industrial Pharmacy”

This study evaluated new aqueous gel formulations of minoxidil without irritants and found that the calcium alginate gel showed the best performance in terms of drug release and skin permeation.

research Development and Optimization of Finasteride-Cinnamon Oil-Loaded Ethanol-Free Microemulsions for Transdermal Delivery

January 2021 in “Social Science Research Network”

In this study, researchers developed and optimized ethanol-free microemulsion systems for transdermal finasteride delivery, finding that the predicted formulations closely matched their physical and chemical characteristics, potentially reducing adverse effects compared to oral administration.

research Formulasi Dan Uji Stabilitas Hair Tonic Kombinasi Ekstrak Daun Kelor (Moringa oleifera Lam.) Dan Madu Dengan Variasi Propilen Glikol

July 2026 in “Jurnal Multidisiplin Dehasen (MUDE)”

In this study, hair tonic formulations containing moringa leaf extract and honey were tested for stability and found to remain stable and non-irritating after storage, meeting specific quality standards.

research Clinical Efficacy, Cosmetic Acceptability, and Local Tolerability of a New Formulation of Topical 5% Minoxidil without Propylene glycol: A 6-month, Multicentre, Real-life, Prospective, Assessor-Blinded Study in 196 Subjects with Hair Loss. The andldquo;NOMINALandrdquo; Trial

January 2021 in “Journal of clinical & experimental dermatology research”

This study found that a new propylene glycol-free 5% minoxidil lotion demonstrated good clinical efficacy and very good cosmetic acceptability and tolerability after six months of use in patients with androgenetic alopecia, showing results comparable to traditional formulations containing propylene glycol.

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community Alcohol& Propylene glycol- Free minoxidil?

3 upvotes 3 months ago

The user is experiencing dry and flaky hair from topical 5% minoxidil and is seeking recommendations for alcohol and propylene glycol-free minoxidil brands. They are not interested in oral minoxidil due to concerns about body hair.

community Is it possible to make a propylene glycol free Minoxidil + Tretenoin solution?

in Minoxidil 2 upvotes 10 months ago

Creating a propylene glycol-free Minoxidil and Tretinoin solution to reduce skin irritation and enhance effectiveness. An emulsifier like lecithin can help mix Tretinoin properly, and Minoxidil foam is an alternative without propylene glycol.

community Finally live! alcohol-free, propylene glycol–free topical finasteride foam

17 upvotes 10 months ago

A new alcohol-free, propylene glycol-free topical finasteride foam is available for prescription in Canada and the USA, offering a cleaner alternative for hair loss treatment. The product also offers a combination of 0.1% finasteride with 5% minoxidil and aims to be affordable and less irritating for sensitive scalps.

community Anyone in Australia found topical versions of minoxidil and finasteride that are free of Propylene Glycol?

in Treatment 1 upvotes 2 years ago

A user is seeking topical versions of minoxidil and finasteride in Australia that do not contain propylene glycol. They are looking for alternatives due to potential irritation from propylene glycol.

community Minoxidil liquid gives me flakes /has anyone tried PG-free liquid with a scalp applicator?

2 upvotes 1 month ago

Liquid minoxidil causes scalp flaking due to propylene glycol, leading some to consider switching to foam or PG-free liquid with applicators. Foam is often recommended for ease and effectiveness, while PG-free liquid is less common but can reduce irritation.

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Learn

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learn Pentylene Glycol

learn Butylene glycol

learn Overview

learn propylene glycol

learn hexylene glycol

learn Finasteride

Do you want finasteride to penetrate better? The ideal solvent to maximize its effect. Formulation sources describe propylene glycol and microemulsion vehicles as increasing how much topical finasteride crosses the skin, but better penetration has not been shown to mean better hair results, and it also raises systemic exposure. The vehicle and strength are decisions for a prescriber or compounding pharmacist.

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