Extemporaneous Topical Minoxidil Solutions for the Treatment of Androgenetic Alopecia: Stability Studies and Incorporation Tests of Active Pharmaceutical Ingredients in Aloplus Total Base

The paper presents a new method for producing minoxidil lotions using Aloplus Total, a propylene glycol-free liquid base, for the treatment of androgenetic alopecia. The intrinsic solubility of minoxidil in this base was found to be 85.93 mg/mL ± 4.17 mg/mL (8.64% w/w ± 0.42% w/w) at 25°C. The study conducted a comprehensive chemical and physical stability test on 8% w/w minoxidil lotions and found them to be stable for more than 180 days when stored at 25°C or 40°C. The paper also carried out incorporation tests of different active pharmaceutical ingredients that can be combined with 5% w/w minoxidil, which were successful. This indicates that Aloplus Total is a useful liquid vehicle for the preparation of minoxidil-based topical lotions for a synergistic treatment of androgenetic alopecia.