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Impact of a Topical Lotion, CG428, on Permanent Chemotherapy-Induced Alopecia in Breast Cancer Survivors: A Pilot Randomized Double-Blind Controlled Clinical Trial (VOLUME RCT)

research Impact of a topical lotion, CG428, on permanent chemotherapy-induced alopecia in breast cancer survivors: a pilot randomized double-blind controlled clinical trial (VOLUME RCT)

3 citations , July 2019 in “Supportive Care in Cancer”

The lotion CG428 did not show effectiveness in treating permanent hair loss in breast cancer survivors.

research 595 In vitro evaluation of skin distribution and human dermal papilla cells proliferation for minoxidil 5% topical lotion hydrogel

July 2022 in “Journal of Investigative Dermatology”

This study found that a new alcohol-free minoxidil hydrogel formulation showed comparable in vitro efficacy and skin absorption to the commercial minoxidil product for treating androgenetic alopecia.

research Topical lotion beneficial in androgenetic alopecia

November 1996 in “Inpharma Weekly”

Lotion with piroctone olamine and triclosan improves hair loss in men.

Comparison of the Efficacy of Topical Methotrexate 1% Gel Versus Topical Betamethasone Dipropionate 0.05% Lotion in the Treatment of Localized Scalp Alopecia Areata in a Tertiary Care Institute of Central India: A Randomized Control Trial

research Comparison of the Efficacy of Topical Methotrexate 1% gel Versus Topical Betamethasone Dipropionate 0.05% Lotion in the Treatment of Localized Scalp Alopecia Areata in a Tertiary Care Institute of Central India: A Randomized Control Trial

August 2025 in “Indian Dermatology Online Journal”

In this study, both methotrexate gel and betamethasone lotion were found to be effective and safe treatments for localized alopecia areata, with similar overall response rates. However, methotrexate gel had a higher incidence of local side effects, such as irritant dermatitis and itching.

research Topical Glycosaminoglycan Lotion and Microneedling Therapy for Androgenetic Alopecia

January 2024 in “International Journal of Trichology”

This study found that combining microneedling with a topical glycosaminoglycan lotion improved hair density and follicular thickness in patients with androgenetic alopecia, with no adverse effects except mild pain, suggesting potential synergistic benefits as a treatment.

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Learn

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learn Finasteride

Topical or oral? Choosing between pills and lotions according to your case. Topical finasteride offers localized treatment with fewer systemic side effects than oral finasteride.

learn Saw Palmetto

Is it better to take saw palmetto in capsules or use it in lotions? The evidence does not show one form is better: the only head-to-head hair study of oral saw palmetto compared it with finasteride (and finasteride did better), the topical evidence is a single uncontrolled pilot, and there is no trial comparing capsules with lotions.

learn Adenosine

nucleoside used for hair regrowth stimulant properties

learn Overview

learn Neem Oil

natural substance from Neem tree with medicinal and pesticidal properties

learn Cetirizine

Is topical cetirizine effective for androgenetic alopecia in women? Topical cetirizine is not an approved product and its use for female-pattern hair loss is off-label. The evidence is one small unblinded pilot study in mixed-sex patients and one randomized trial in 66 women where cetirizine was added to minoxidil; it is unproven on its own.

learn Estradiol

How does topical Estradiol compare to oral Estradiol in treating alopecia? Topical estradiol delivers hormone to the scalp with less systemic exposure, but evidence is thin and it is still a hormone. It needs a doctor's supervision, and people with estrogen-sensitive cancers must not use it without medical approval.

learn Glycerin

Does topical glycerin have any effect on hair thickness or follicle function? Topical glycerin primarily hydrates hair but does not increase thickness or follicle function.

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Community Join

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community Hair Lotion Suggestion Needed!

3 upvotes 1 year ago

A user is seeking suggestions for a custom hair lotion mix containing minoxidil, finasteride, caffeine, niacinamide, and biotin. Another user suggests adding tretinoin, topical valproate, and bimatoprost.

community Galenic lotion. Science behind the components

in Treatment 1 upvotes 1 year ago

A user is considering a hair loss treatment lotion containing minoxidil, adenosine, caffeine, melatonin, and azelaic acid, questioning the interaction between caffeine and adenosine receptors. Another user suggests adding a topical anti-DHT ingredient like spironolactone, noting it should not be taken orally by men.

community 6 month progress (topical min + oral fin)

in Progress Pictures 27 upvotes 1 year ago

A user shared their 6-month hair loss progress using topical minoxidil, oral finasteride, and microneedling, reporting positive results despite recent shedding. They also mentioned using rosemary oil and a special head lotion for dandruff.

community How to make topical finasteride at home

4 upvotes 11 months ago

A user in Russia is trying to make topical finasteride at home using ethanol, finasteride tablets, water, and propylene glycol due to unavailability in their country. They are concerned about tablet residue and considering using isopropyl alcohol or adding finasteride to a hair growth lotion.

community Already take oral minoxidil 5 mg daily. Any use of applying topical minoxidil as well?

1 upvotes 1 year ago

The conversation discusses whether using topical minoxidil in addition to oral minoxidil 5 mg daily will enhance hair growth. The user also applies a Biotinyl tripeptide cream/lotion and is concerned about the efficacy and side effects of oral versus topical minoxidil.

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