Hair-Growth Stimulation by Conditioned Medium from Vitamin D3-Activated Preadipocytes in C57BL/6 Mice

    March 2015 in “ Life sciences ”
    M. Jung, Soogyeong Ha, Scarlett Yoona Huh, Seung Beom Park, Sangyoon Kim, Yoolhee Yang, Daejin Kim, Dae Young Hur, Hyunjo Jeong, Sa Ik Bang, Hyun-Jeong Park, Daeho Cho
    TLDR Vitamin D3-activated cell byproduct promotes hair growth in mice by increasing blood vessel growth.
    The study investigated the effect of conditioned medium (CM) from vitamin D3 (Vd3) pre-activated preadipocytes on hair growth in C57BL/6 mice. The results showed that CM from Vd3 pre-activated preadipocytes significantly promoted hair regeneration, which was associated with increased levels of vascular endothelial growth factor (VEGF) and enhanced angiogenesis. The signaling mechanism involved the ERK1/2 pathway, as Vd3-enhanced VEGF production was reduced by an ERK1/2 inhibitor. This was the first report demonstrating that CM from Vd3 pre-activated preadipocytes could stimulate hair growth through angiogenesis, suggesting a potential new strategy for treating hair loss.
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