Hair-Growth Stimulation by Conditioned Medium from Vitamin D3-Activated Preadipocytes in C57BL/6 Mice

May 2015 in “ Life sciences ”

M. Jung, Soogyeong Ha, Scarlett Yoona Huh, Seung Beom Park, Sangyoon Kim, Yoolhee Yang, Daejin Kim, Dae Young Hur, Hyunjo Jeong, Sa Ik Bang, Hyun-Jeong Park, Daeho Cho

conditioned medium vitamin D3 preadipocytes hair growth vascular endothelial growth factor VEGF angiogenesis ERK1/2 pathway ERK1/2 inhibitor CM Vd3

TLDR Vitamin D3-activated cell byproduct promotes hair growth in mice by increasing blood vessel growth.

The study investigated the effect of conditioned medium (CM) from vitamin D3 (Vd3) pre-activated preadipocytes on hair growth in C57BL/6 mice. The results showed that CM from Vd3 pre-activated preadipocytes significantly promoted hair regeneration, which was associated with increased levels of vascular endothelial growth factor (VEGF) and enhanced angiogenesis. The signaling mechanism involved the ERK1/2 pathway, as Vd3-enhanced VEGF production was reduced by an ERK1/2 inhibitor. This was the first report demonstrating that CM from Vd3 pre-activated preadipocytes could stimulate hair growth through angiogenesis, suggesting a potential new strategy for treating hair loss.

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research Ultraviolet B Preconditioning Enhances the Hair Growth-Promoting Effects of Adipose-Derived Stem Cells Via Generation of Reactive Oxygen Species

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research Stem Cells and Alopecia: A Review of Pathogenesis

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research Successful Treatment of Alopecia Areata with Topical Calcipotriol

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research Advances in the Management of Alopecia Areata

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research Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling

499 citations , September 2011 in “Cell”

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research Hair Growth Promoting Effects of Adipose Tissue-Derived Stem Cells

81 citations , February 2010 in “Journal of Dermatological Science”

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research Hair Growth Stimulated by Conditioned Medium of Adipose-Derived Stem Cells Is Enhanced by Hypoxia: Evidence of Increased Growth Factor Secretion

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research TGF-β2 Is Specifically Expressed in Human Dermal Papilla Cells and Modulates Hair Folliculogenesis

43 citations , November 2009 in “Journal of Cellular and Molecular Medicine”

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research Angiogenin Is Expressed in Human Dermal Papilla Cells and Stimulates Hair Growth

20 citations , October 2008 in “Archives of dermatological research”

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research Vitamin D and Human Health: Lessons from Vitamin D Receptor Null Mice

1533 citations , October 2008 in “Endocrine reviews”

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research Increased Rate of Hair Regrowth in Mice with Constitutive Overexpression of Del1

6 citations , May 2008 in “Journal of Surgical Research”

Mice genetically modified to produce more Del1 protein had faster hair regrowth.

research Human Hair Growth Enhancement In Vitro By Green Tea Epigallocatechin-3-Gallate (EGCG)

108 citations , August 2007 in “Phytomedicine”

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research Effect of Minoxidil on Proliferation and Apoptosis in Dermal Papilla Cells of Human Hair Follicle

149 citations , April 2004 in “Journal of Dermatological Science”

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research Vitamin D3 Analogs Stimulate Hair Growth in Nude Mice

40 citations , November 2002 in “Endocrinology”

Vitamin D3 analogs can promote hair growth in mice genetically prone to hair loss.

research Lack of the Vitamin D Receptor Is Associated with Reduced Epidermal Differentiation and Hair Follicle Growth

180 citations , January 2002 in “The journal of investigative dermatology/Journal of investigative dermatology”

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research Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis

520 citations , February 2001 in “Journal of Clinical Investigation”

VEGF helps hair grow and determines follicle size by increasing blood vessel growth.

research Principles of Hair Cycle Control

109 citations , December 1998 in “The Journal of Dermatology”

Manipulating the catagen and telogen phases of hair growth could lead to treatments for hair disorders.

research Growth Factors and Cytokines in Hair Follicle Development and Cycling: Recent Insights from Animal Models and the Potentials for Clinical Therapy

100 citations , November 1996 in “Molecular Medicine Today”

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