Promotion of Hair Growth by a Conditioned Medium from Human Umbilical Cord Mesenchymal Stem Cells Cultivated in a 3D Scaffold of Gelatin Sponge

    May 2024 in “ European journal of medical research ”
    Jintao Ni, Danyan Ye, Weiping Zeng, Siyi Ma, Zhixia Wang, Yuping Kuang, Lüjun Yang
    Image of study
    TLDR A special medium from stem cells significantly boosts hair growth and could help treat hair loss.
    The study concludes that a conditioned medium from human umbilical cord mesenchymal stem cells (HuMSCs) cultivated in a 3D gelatin sponge scaffold (GS-HuMSCs-CM) significantly promotes hair growth in C57BL/6J mice by inducing and prolonging the anagen phase and enhancing skin angiogenesis. The GS-HuMSCs-CM group showed superior hair regrowth compared to HuMSCs alone, with increased hair length, diameter, and growth rate, achieving 95%-100% hair coverage by day 14. The medium also promoted neo-angiogenesis, leading to higher blood vessel density, which supports hair growth. This suggests that GS-HuMSCs-CM could be a promising strategy for treating alopecia, offering advantages in use, storage, and transportation over traditional stem cell therapies. Future research could focus on identifying specific proteins in the medium that promote hair growth.
    Discuss this study in the Community →

    Research cited in this study

    22 / 22 results

    Related Community Posts Join

    6 / 1000+ results

      community Scientific evidence for Peppermint & Rosemary oils + My Experience

      in Research/Science  114 upvotes 2 years ago
      Natural treatments for hair loss, specifically peppermint oil and rosemary oil; how they can be used as a supplementary or alternative treatment to pharmaceuticals such as finasteride and minoxidil; and the personal experience of the user Divallo, who has seen an increase in density and thickness after using these oils for around 2.5 years. The post also touches on the potential antifungal properties of the oils and their effects on cutaneous blood flow.

      community Comprehensive Microneedling Guide

      in Microneedling  290 upvotes 3 years ago
      Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

      community Am I missing something with pp405?

      in Research/Science  37 upvotes 8 months ago
      PP405 is discussed as a potential hair growth stimulant, possibly more effective than minoxidil, but not a cure for hair loss. There is skepticism about its ability to regrow "deadzones," and concerns about its impact on those with hair transplants.

      community Dry hair vs wet hair, is minox, microneedling and ketoconazole enough?

      in Treatment  110 upvotes 2 years ago
      The conclusion of the conversation is that using minoxidil, finasteride, and ketoconazole may not be enough to address hair loss caused by DHT. Some users recommend starting finasteride to prevent further hair loss, while others express concerns about potential side effects.

    Similar Research

    5 / 1000+ results