6-Gingerol Inhibits Hair Cycle via Induction of MMP2 and MMP9 Expression

    Chun‐Han Hou, Yong Miao, Hang Ji, Susheng Wang, Gang Liang, Zhihua Zhang, Wei‐Jin Hong
    Image of study
    TLDR 6-Gingerol from ginger may slow down hair growth by affecting certain enzymes and growth factors.
    In the 2017 study, researchers investigated the effects of 6-Gingerol, a major component of ginger, on hair growth in mice. Mice were divided into five groups and treated with varying concentrations of 6-Gingerol after hair depilation. The study found that 6-Gingerol, particularly at a concentration of 1 mg/mL, significantly inhibited hair growth. This was evidenced by a reduction in hair re-growth ratio, hair follicle number, and hair follicle length. The suppression of hair growth was associated with increased expression of MMP2 and MMP9, enzymes that can affect the hair cycle. Additionally, 6-Gingerol altered the levels of growth factors involved in hair follicle regulation, decreasing the concentrations of EGF, KGF, VEGF, and IGF-1, while increasing TGF-β concentration. The results suggest that 6-Gingerol could potentially be used as a hair growth suppressive agent by influencing MMP2 and MMP9 expression and interfering with the hair cycle.
    Discuss this study in the Community →

    Research cited in this study

    18 / 18 results

    Related Community Posts Join

    6 / 1000+ results

      community 6 months on dutast and minoxodil, hair growing like weeds now!

      in Progress Pictures  541 upvotes 2 days ago
      A woman experienced significant hair regrowth after six months of using dutasteride and minoxidil, despite initial hair loss due to androgenetic alopecia. She reported minimal side effects and highlighted the effectiveness of these treatments for women, despite doctors' hesitancy to prescribe them.

      community 6 months progress topical min/fin (19)

      in Progress Pictures  99 upvotes 4 days ago
      The user is using a treatment of topical minoxidil 7% and finasteride 0.1% twice daily, along with a low-level laser therapy cap, biotin, and collagen supplements, and is seeing good progress on the hairline and temples but not the midscalp. They experienced initial shedding, saw results by month three, and are happy with the progress, though some users express concern about using finasteride at a young age.

      community 6 months progress on fin/min...!

      in Progress Pictures  58 upvotes 1 week ago
      The user shared their 6-month progress using finasteride and minoxidil for hair loss, noting improvements and reduced shedding. They decreased their minoxidil dosage from 10% to 5% and no longer need biotin, with no side effects from finasteride.

    Related Research

    2 / 2 results