6-Gingerol Inhibits Hair Cycle via Induction of MMP2 and MMP9 Expression

    December 2017 in “ Anais da Academia Brasileira de Ciências ”
    Chun‐Han Hou, Yong Miao, Hang Ji, Susheng Wang, Gang Liang, Zhihua Zhang, Wei‐Jin Hong
    Image of study
    TLDR 6-Gingerol from ginger may slow down hair growth by affecting certain enzymes and growth factors.
    In the 2017 study, researchers investigated the effects of 6-Gingerol, a major component of ginger, on hair growth in mice. Mice were divided into five groups and treated with varying concentrations of 6-Gingerol after hair depilation. The study found that 6-Gingerol, particularly at a concentration of 1 mg/mL, significantly inhibited hair growth. This was evidenced by a reduction in hair re-growth ratio, hair follicle number, and hair follicle length. The suppression of hair growth was associated with increased expression of MMP2 and MMP9, enzymes that can affect the hair cycle. Additionally, 6-Gingerol altered the levels of growth factors involved in hair follicle regulation, decreasing the concentrations of EGF, KGF, VEGF, and IGF-1, while increasing TGF-β concentration. The results suggest that 6-Gingerol could potentially be used as a hair growth suppressive agent by influencing MMP2 and MMP9 expression and interfering with the hair cycle.
    Discuss this study in the Community →

    Research cited in this study

    18 / 18 results

    Related Community Posts Join

    6 / 1000+ results

      community 6 months progress happy so far

      in Progress Pictures  319 upvotes 1 week ago
      The user reported significant hair growth progress after six months using daily Dutasteride 0.5mg and oral Minoxidil 5mg. Many users expressed amazement and inquired about side effects, age, and product brands.

      community 6 month update on DUT AND minoxidil

      in Progress Pictures  69 upvotes 2 weeks ago
      The user has been using a regimen of dutasteride (DUT) and topical minoxidil (1ml once a day) for six months, resulting in hair regrowth and increased thickness. The user reports no side effects and mentions that the shedding phase lasted about a month.

      community 6 Month Progress Update - Long Journey

      in Progress Pictures  474 upvotes 2 weeks ago
      Significant hair regrowth was achieved over six months using minoxidil, finasteride, microneedling, biotin and collagen shampoo, and MSM powder. The user feels more confident and may consider a hair transplant if necessary.

      community 6 Week Dut/Minox/Nizoral - Hair-loss Reversal Update.

      in Is this regrowth?  182 upvotes 3 weeks ago
      A user shared their 6-week update on using 0.5mg dutasteride daily, 2.5mg oral minoxidil, and Nizoral for hair loss, noting noticeable regrowth but experiencing side effects like lower sex drive and brain fog. The conversation includes suggestions for additional treatments and discussions about hair transplant costs.

    Related Research

    2 / 2 results