Lack of Collagen VI Promotes Wound-Induced Hair Growth

    May 2015 in “ Journal of Investigative Dermatology ”
    Peiwen Chen, Matilde Cescon, Paolo Bonaldo
    Studysummary This study found that collagen VI influences hair follicle growth and wound-induced regrowth by activating the Wnt/β-catenin signaling pathway in mice, suggesting potential therapeutic targets for hair loss.
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    Research cited in this study 14

    1. Keratin 79 Identifies a Novel Population of Migratory Epithelial Cells That Initiates Hair Canal Morphogenesis and Regeneration Development · 2013
    2. Fgf9 From Dermal γδ T Cells Induces Hair Follicle Neogenesis After Wounding Nature Medicine · 2013
    3. Highly Upregulated Lhx2 in the Foxn1−/− Nude Mouse Phenotype Reflects a Dysregulated and Expanded Epidermal Stem Cell Niche PloS one · 2013
    4. Prostaglandin D2 Inhibits Wound-Induced Hair Follicle Neogenesis Through the Receptor Gpr44 Journal of Investigative Dermatology · 2012
    5. Epithelial Wnt Ligand Secretion Is Required for Adult Hair Follicle Growth and Regeneration Journal of Investigative Dermatology · 2012
    6. Dermal β-Catenin Activity in Response to Epidermal Wnt Ligands Is Required for Fibroblast Proliferation and Hair Follicle Initiation Development · 2012
    7. Dissecting the Bulge in Hair Regeneration Journal of Clinical Investigation · 2012
    8. The Basement Membrane Of Hair Follicle Stem Cells Is A Muscle Cell Niche Cell · 2011
    9. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007
    10. Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis Nature Medicine · 2005
    11. Expression Profiling and Cellular Localization of Genes Associated with the Hair Cycle Induced by Wax Depilation ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2005
    12. Enrichment for Living Murine Keratinocytes from the Hair Follicle Bulge with the Cell Surface Marker CD34 Journal of Investigative Dermatology · 2003
    13. Molecular Mechanisms Regulating Hair Follicle Development ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002
    14. Expression of Calcium-Binding S100 Proteins A4 and A6 in Regions of the Epithelial Sac Associated with the Onset of Hair Follicle Regeneration Journal of Investigative Dermatology · 2001

    Related research 6

    1. Dysfunction of Hair Follicle Mesenchymal Progenitors Is Associated with Age-Related Hair Loss ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2019
    2. Lack of Collagen VI Promotes Wound-Induced Hair Growth Journal of Investigative Dermatology · 2015
    3. Protection Against Chemotherapy-Induced Alopecia: Targeting ATP-Binding Cassette Transporters in the Hair Follicle Trends in pharmacological sciences · 2013
    4. Pathobiology of Chemotherapy-Induced Hair Loss The Lancet Oncology · 2013
    5. Epithelial Wnt Ligand Secretion Is Required for Adult Hair Follicle Growth and Regeneration Journal of Investigative Dermatology · 2012
    6. Towards a Molecular Understanding of Hair Loss and Its Treatment Trends in Molecular Medicine · 2001