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Glossary Collagen

protein providing structure and strength to connective tissues

Collagen is a protein that serves as a key structural component in various connective tissues, including skin, hair, nails, bones, and tendons. It provides strength and elasticity, helping to maintain the integrity and resilience of these tissues. As we age, collagen production decreases, which can lead to signs of aging such as wrinkles and weakened joints.

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Research

5 / 1000+ results

research Basement Membrane Zone Remodeling During Appendageal Development in Human Fetal Skin. The Absence of Type VII Collagen is Associated with Gelatinase-A (MMP2) Activity

42 citations , February 2000 in “Journal of Investigative Dermatology”

This study found that Gelatinase A activity is linked to the absence of type VII collagen during human fetal skin development, indicating its role in remodeling the basement membrane zone.

research Lack of Collagen VI Promotes Wound-Induced Hair Growth

32 citations , May 2015 in “Journal of Investigative Dermatology”

This study found that collagen VI influences hair follicle growth and wound-induced regrowth by activating the Wnt/β-catenin signaling pathway in mice, suggesting potential therapeutic targets for hair loss.

research Regenerative Hair Pigmentation via Skin Organoids: Adaptive Patterning Mediated by Collagen VI and Semaphorin 3C

July 2025 in “Advanced Science”

In this study, researchers discovered two new signaling pathways that regulate how melanocytes establish pigment patterns in reconstituted hair-bearing skin, offering insights that could inform strategies to prevent hair greying.

research Alopecia in Patients with Collagen VI-Related Myopathies: A Novel/Unrecognized Scalp Phenotype

April 2023 in “International journal of molecular sciences”

This study found that scalp disorders, such as hair loss and itching, can be associated with collagen VI mutations, thus highlighting the need to investigate scalp involvement in these patients.

research Role of collagen VI in peripheral nerves and wound-induced hair regrowth

January 2015

This study found that collagen VI is crucial for peripheral nerve function and regeneration, and its absence promotes abnormal hair regrowth after skin wounding in mice, revealing potential therapeutic targets for nerve injuries and hair loss.

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Community Join

5 / 509 results

community 5 weeks Min + vit D/Zinc/biotin/collagen progress

5 upvotes 3 years ago

The user is using Minoxidil, vitamin D, zinc, biotin, collagen, and micro-needling for hair regrowth. Some users suggest biotin and collagen are ineffective and emphasize the need for a DHT blocker for lasting results.

community Why hasn’t anybody or any company done experiments on whether minoxidil and finasteride have effects on human collagen and elastin after a year of use compared to placebo? (In vivo not vitro)

6 upvotes 7 months ago

The conversation discusses the lack of in vivo studies on the effects of minoxidil and finasteride on human collagen and elastin after a year of use. It highlights the potential benefits of such research for understanding side effects and improving sales, despite challenges like cost and competition.

community do any supplements actually work?

6 upvotes 2 years ago

A user asked if collagen or hair growth supplements made their hair thicker. Another user suggested that Vitamin D might help if deficient.

community Tretinoin to counter-act Minoxidil's skin effects?

5 upvotes 6 years ago

Minoxidil may cause dark circles and affect collagen, and Tretinoin might help counteract these effects. Users suggest caution with Tretinoin due to potential Vitamin A toxicity and recommend using it sparingly with sunscreen and moisturizer.

community Microneedling scarring or not? Doesn't it make the situation worse?

in Microneedling 6 upvotes 1 year ago

Microneedling can help with hair loss by inducing collagen if done correctly, but improper technique may cause scarring and worsen the condition. Some users apply dissolved vitamin C before and after microneedling to enhance results.

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