Increased Rate of Hair Regrowth in Mice with Constitutive Overexpression of Del1

In the 2008 study, researchers found that mice with a constitutive overexpression of Developmental Endothelial Locus-1 (Del1) in basal keratinocytes showed an increased rate of hair regrowth following depilation, with significant differences observed between transgenic K14-Del1 mice and wild-type littermates. Hair regrowth was visible by day 15 in K14-Del1 mice compared to day 18 in wild-type mice, with a sample size of 8 mice per group (P < 0.05). The study also noted a dose effect, where mice with two copies of the Del1 transgene exhibited more vigorous hair regrowth than those with one copy. While Del1 was found to be naturally expressed during the anagen phase of hair growth and its overexpression did not affect wound healing or skin vascularity, the study suggests that Del1 plays a role in hair follicle maturation and may prevent apoptosis of cells involved in this process. However, the study acknowledges that further research is needed to fully understand Del1's role in hair follicle development, and it does not provide detailed information on the experimental design or the number of mice used in all experiments.