Reprofiling Synthetic Glucocorticoid-Induced Leucine Zipper Fusion Peptide as a Novel and Effective Hair Growth Promoter

May 2024 in “ Archives of Dermatological Research ”

Sahar Emami Naeini, Bidhan Bhandari, Jules Gouron, Hannah M. Rogers, Pablo Shimaoka Chagas, Golnaz Emami Naeini, Henrique Izumi Shimaoka Chagas, Hesam Khodadadi, Évila Lopes Salles, Mohammad Seyyedi, Jack C. Yu, Beata K Grochowska, Lei P. Wang, Babak Baban

synthetic glucocorticoid-induced leucine zipper fusion peptide TAT-GILZ hair growth promoter hair follicle stem cells regulatory T cells glucocorticoid receptors

TLDR TAT-GILZ peptide promotes hair growth by boosting stem cell activity.

This study investigates the synthetic glucocorticoid-induced leucine zipper fusion peptide, TAT-GILZ, as a potential hair growth promoter. Conducted on 9–12 week-old male BALB/c and nude mice, the research found that TAT-GILZ accelerated hair growth on depilated skin and induced growth on athymic mice. The peptide enhanced hair follicle stem cells and increased counter-inflammatory signals, such as regulatory T cells and glucocorticoid receptors, suggesting TAT-GILZ as a promising alternative therapy for hair growth by boosting stem cell activity and maintaining homeostasis.

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